Highlights

  • Deep mutational scanning

    High-resolution approach has been used to assess the effect of more than 6000 protein-coding variants in a G protein-coupled receptor associated with obesity.

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Reviewed Preprint Updated
  • eLife wins award for UX

    eLife wins user experience (UX) award from OpenAthens for its user-driven approach to the design of Reviewed Preprints.

    Press Pack
  • Social behaviors in mice

    A cell atlas for the preoptic area of the brain could be used to investigate how neuronal traits may be evolving to give rise to innate differences in social behavior across species.

    Jenny Chen, Phoebe R Richardson ... Hopi E Hoekstra
    Reviewed Preprint Updated

Latest research

    1. Cell Biology
    2. Developmental Biology

    Transcriptional Dynamics Uncover the Role of BNIP3 in Mitophagy during Muscle Remodeling in Drosophila

    Hiroki Taoka, Tadayoshi Murakawa ... Naonobu Fujita
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Epidemiology and Global Health

    Founder effects arising from gathering dynamics systematically bias emerging pathogen surveillance

    Bradford P Taylor, William P Hanage
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    Brief disruption of activity in a subset of dopaminergic neurons during consolidation impairs long-term memory by fragmenting sleep

    Lin Yan, Litao Wu ... Chang Liu
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and replacement from precursors

    Jodie Chandler, M Elise Bullock ... Andrew J Yates
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Neuroscience

    Representation of male features in the female mouse Accessory Olfactory Bulb, and their stability during the estrus cycle

    Oksana Cohen, Yoram Ben-Shaul
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience

    Motor unit mechanisms of speed control in mouse locomotion

    Kyle Thomas, Rhuna Gibbs ... Samuel J Sober
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coral anthozoan-specific opsins employ a novel chloride counterion for spectral tuning

    Yusuke Sakai, Saumik Sen ... Akihisa Terakita
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Structural Biology and Molecular Biophysics

    Functionally Important Residues from Graph Analysis of Coevolved Dynamic couplings

    Manming Xu, Sarath Chandra Dantu ... Shozeb Haider
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli

    Irina Kalita, Ira Alexandra Iosub ... Meriem El Karoui
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing