Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics

    Specific Modulation of CRISPR Transcriptional Activators through RNA-Sensing Guide RNAs in Mammalian Cells and Zebrafish Embryos

    Oana Pelea, Sarah Mayes ... Tatjana Sauka-Spengler
    1. Genetics and Genomics
    2. Medicine

    Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

    Lianlei Wang, Sen Zhao ... Nan Wu
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Signatures of transposon-mediated genome inflation, host specialization, and photoentrainment in Entomophthora muscae and allied entomophthoralean fungi

    Jason E Stajich, Brian Lovett ... Carolyn Elya
    Entomophthora muscae has one of the largest fungal genomes (1.03 Gb) owing to extensive proliferation of transposable elements.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis facilitates functional evolution in an ancient transcription factor

    Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton
    A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
    1. Cell Biology
    2. Genetics and Genomics

    SCC3 is an axial element essential for homologous chromosome pairing and synapsis

    Yangzi Zhao, Lijun Ren ... Zhukuan Cheng
    1. Cell Biology
    2. Genetics and Genomics

    Aberrant methylation and expression of TNXB promotes chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

    Jiali Chen, Zeng Qinghe ... Hongting Jin
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

    Yongjin Liu, Sandra LaBonte ... Paul D. Straight
    1. Genetics and Genomics
    2. Medicine

    IQCH regulates spermatogenesis by interacting with CaM to promote the expression of RNA-binding proteins

    Tiechao Ruan, Ruixi Zhou ... Ying Shen
    1. Genetics and Genomics
    2. Neuroscience

    The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Cognitive Aging

    Yifei Weng, Shiyi Zhou ... Coleen T. Murphy
    1. Developmental Biology
    2. Genetics and Genomics

    Astrogliosis and Neuroinflammation Underlie Scoliosis Upon Cilia Dysfunction

    Morgane Djebar, Isabelle Anselme ... Christine Vesque
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Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Genetics and Genomics
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    Read public reviews for ‘A “tour-de-force” study of neuronal maturation’

    1. Genetics and Genomics

    Quantitative Genetics: Explore our collection of articles

    Edited by Patricia Wittkopp et al.

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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