Browse our latest research

Page 2 of 1,561
    1. Medicine
    2. Neuroscience

    Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    Yunlu Xue, Yimin Zhou, Constance L Cepko
    Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
    1. Neuroscience

    Parallel processing of quickly and slowly mobilized reserve vesicles in hippocampal synapses

    Juan Jose Rodriguez Gotor, Kashif Mahfooz ... John F Wesseling
    Reevaluation of reserve synaptic vesicle pools supports a new model of presynaptic function.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Dynamic modes of Notch transcription hubs conferring memory and stochastic activation revealed by live imaging the co-activator Mastermind

    F Javier DeHaro-Arbona, Charalambos Roussos ... Sarah Bray
    Live imaging of the Notch co-activator Mastermind reveals that it promotes the formation of a dynamic transcription hub in Notch ON nuclei, conferring probabilistic transcription and providing a template for signal memory.
    1. Evolutionary Biology
    2. Neuroscience

    Large-scale deorphanization of Nematostella vectensis neuropeptide G protein-coupled receptors supports the independent expansion of bilaterian and cnidarian peptidergic systems

    Daniel Thiel, Luis Alfonso Yañez Guerra ... Gáspár Jékely
    The identification of 31 neuropeptide GPCRs in the sea anemone Nematostella vectensis provides a rich resource to study peptidergic signaling in cnidarians and suggests that cnidarian and bilaterian peptidergic systems diversified independent from each other from a few ancestral systems.
    1. Neuroscience

    Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats

    Silvia Cardani, Tara A Janes ... Silvia Pagliardini
    Knockdown of PHOX2B in the chemosensitive area of the retrotrapezoid nucleus of adult rats reduces CO2 responses and the expression of the proton sensors TASK2 and GPR4.
    1. Developmental Biology

    Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

    Rieko Asai, Vivek N Prakash ... Takashi Mikawa
    At the onset of gastrulation, primitive streak morphogenesis that requires mitosis along the embryo midline, persists even with a disrupted bilateral cell flow.
    1. Neuroscience

    Experience transforms crossmodal object representations in the anterior temporal lobes

    Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan D Barense
    Anterior temporal lobe structures differentiated learned from non-learned crossmodal objects, evidence of integrated crossmodal object representations.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MEMO1 binds iron and modulates iron homeostasis in cancer cells

    Natalia Dolgova, Eva-Maria E Uhlemann ... Oleg Y Dmitriev
    Cancer metastasis modulator MEMO1 binds iron and is involved in regulating iron homeostasis in cancer cells.
    1. Neuroscience

    Shortcutting from self-motion signals: quantifying trajectories and active sensing in an open maze

    Jiayun Xu, Mauricio Girardi-Schappo ... Leonard Maler