Molecular matchmakers

Latest research

1. 1. Cancer Biology

   STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer

   Huan Fang, Huichun Liang ... Ceshi Chen
2. 1. Developmental Biology

   Single cell transcriptomics reveals early photoreceptor states, cell-specific transcript isoforms, and cancer-predisposing features

   Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
3. 1. Cancer Biology

   Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

   Sander Frank, Thomas Persse ... Peter S Nelson
4. 1. Evolutionary Biology

   Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation

   Wei-Yun Lai, Sheng-Kai Hsu ... Christian Schlötterer
5. 1. Developmental Biology

   Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

   Tim Casey-Clyde, S John Liu ... David R Raleigh
6. 1. Chromosomes and Gene Expression

   Sir2 and Fun30 regulate ribosomal DNA replication timing via MCM helicase positioning and nucleosome occupancy

   Carmina Lichauco, Eric J Foss ... Antonio Bedalov
7. 1. Cell Biology

   Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

   Yuma Cho, Akari Taniguchi ... Junichi Ikenouchi
8. 1. Cell Biology

   Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

   Yue Miao, Yongtao Du ... Mei Ding

   The USP-50/USP8 protease removes the Rab5 GEF Rabex5 from endosomes while facilitating recruitment of the Rab7 GEF SAND-1/Mon1, promoting endosome maturation.
9. 1. Cancer Biology
   2. Cell Biology

   Automated workflow for the cell cycle analysis of (non-)adherent cells using a machine learning approach

   Kourosh Hayatigolkhatmi, Chiara Soriani ... Simona Rodighiero

   The automated workflow significantly enhances the precision and scalability of cell cycle analysis, enabling high-throughput studies in both non-adherent and adherent cells for advanced cancer research and drug development.
10. 1. Cell Biology

    Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

    Fatima Tleiss, Martina Montanari ... C Leopold Kurz

    Bacterial location quantifications highlights how Drosophila melanogaster larvae discriminate bacteria to isolate and later eliminate pathogens in the anterior midgut through coordinated mechanisms involving reactive oxygen species (ROS) and antimicrobial peptides (AMPs).