Browse the latest research

18,436 results found
    1. Microbiology and Infectious Disease

    PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment

    Binayak Sarkar, Jyotsna Singh ... Rajesh S Gokhale
    In vitro, ex vivo, and in vivo studies reveal that hepatocytes are significantly infected by Mycobacterium tuberculosis which rewires the host cell metabolism to upregulate the lipid biosynthetic pathways.
    1. Developmental Biology
    2. Neuroscience

    Biophysical basis for brain folding and misfolding patterns in ferrets and humans

    Gary PT Choi, Chunzi Liu ... L Mahadevan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Direct lineage conversion of postnatal mouse cortical astrocytes to oligodendrocyte lineage cells

    Justine Bajohr, Erica Y Scott ... Maryam Faiz
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Serratia marcescens Outer Membrane Vesicles rapidly paralyze Drosophila melanogaster through triggering apoptosis in the nervous system

    Bechara Sina Rahme, Roberto E Bruna ... Dominique Ferrandon
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Developmental Biology

    Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

    Heinz-Georg Belting, Ludovico Maggi ... Markus Affolter
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Cancer Biology

    Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma

    Olivia G Waltner, April A Apfelbaum ... Scott N Furlan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Evolutionary Biology

    Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

    Christopher Graser, Wenbo Wu ... Franziska Michor
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

    Sofia Lövestam, Jane L Wagstaff ... Sjors HW Scheres
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Convincing
    1. Neuroscience

    Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns

    F David Wandler, Benjamin K Lemberger ... James M Murray
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing

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