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18,746 results found
    1. Cell Biology

    Human dynein–dynactin is a fast processive motor in living cells

    Vikash Verma, Patricia Wadsworth, Thomas J Maresca
    TIRF imaging of CRISPR-edited human cells shows dynein–dynactin complexes move processively with motility parameters consistent with the presence of multi-dynein assemblies (>one dynein heavy chain dimer per dynactin) in cells.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Cancer Biology
    2. Cell Biology

    Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

    Qi Zhang, Yunfeng Wang ... Shaowei Zhao
    Uev1A and APC/C degrade CycA to counteract oncogenic Ras, thereby protecting against cell death in polyploid Drosophila nurse cells and suppressing overgrowth in diploid germline and human colorectal tumor cells.
    1. Chromosomes and Gene Expression

    Single Domain Antibody Inhibitors Target the Coiled Coil Arms of the Bacillus subtilis SMC complex

    Ophélie Gosselin, Michael Taschner ... Stephan Gruber
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Medicine

    Large-scale synthetic data enable digital twins of human excitable cells

    Pei-Chi Yang, Mao-Tsuen Jeng ... Colleen E Clancy
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell co-mapping reveals relationship between chromatin state and gene expression in early zebrafish development

    Vivek Bhardwaj, Alberto Griffa ... Alexander van Oudenaarden
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

    Kaylee SE van Dijk, Christina Begon-Pescia ... Maria Forlenza
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology

    Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan

    Naci Oz, Hetian Su ... Alaattin Kaya
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Developmental Biology

    Chromatin priming and Hunchback recruitment integrate spatial and temporal cues in Drosophila neuroblasts

    Ayanthi Bhattacharya, Hemalatha Rao, Sonia Q Sen
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    • Solid
    1. Cell Biology

    Orderly mitosis shapes interphase genome architecture

    Krishnendu Guin, Adib Keikhosravi ... Tom Misteli
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
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