Browse the latest research

18,534 results found
    1. Neuroscience

    Disruption of theta-timescale spiking impairs learning but spares hippocampal replay

    Abhilasha Joshi, Alison E Comrie ... Loren M Frank
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    SLC4A1 mutations that cause distal renal tubular acidosis alter cytoplasmic pH and cellular autophagy

    Grace Essuman, Midhat Rizvi ... Emmanuelle Cordat
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology

    map3k1 is required for spatial restriction of progenitor differentiation in planarians

    Bryanna Isela-Inez Canales, Hunter O King, Peter W Reddien
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Epidemiology and Global Health

    Heterogenous associations of polygenic indices of 35 traits with mortality

    Hannu Lahtinen, Jaakko Kaprio ... Pekka Martikainen
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania

    Gabriel H Negreira, Pieter Monsieurs ... Malgorzata A Domagalska
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Neuroscience

    A dynamic scale-mixture model of motion in natural scenes

    Jared M Salisbury, Stephanie E Palmer
    A simple statistical model captures the essential features of object motion in a large database of natural scenes, helping to shed light on the challenges posed to sensory and motor systems.
    1. Medicine

    Association between continuous glucose monitoring-derived metrics and coronary plaque vulnerability: A retrospective exploratory analysis

    Hikaru Sugimoto, Ken-ichi Hironaka ... Shinya Kuroda
    The mean, variance, and autocorrelation of glucose dynamics are independently associated with coronary plaque vulnerability.
    1. Immunology and Inflammation
    2. Neuroscience

    Trained immunity in acute and chronic neurological diseases

    Sijia Zhang, Arthur Liesz
    Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation across neurological diseases, offering new insights into disease mechanisms and potential therapeutic strategies.
    1. Developmental Biology

    Rtf1-dependent transcriptional pausing regulates cardiogenesis

    Adam D Langenbacher, Fei Lu ... Jau-Nian Chen
    Genetic approaches identify Rtf1-dependent transcriptional pausing as an essential mechanism governing the deployment of the cardiac gene program during myocardial differentiation from the mesoderm.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Functionally coupled ion channels begin co-assembling at the start of their synthesis

    Roya Pournejati, Jessica M Huang ... Oscar Vivas
    BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.

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