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19,242 results found
    1. Microbiology and Infectious Disease
    2. Computational and Systems Biology

    A new diagnostic modality for bovine tuberculosis: accurate and robust classification of infected cattle using transcriptomics and machine learning

    John F O’Grady, Adriana Ivich ... David E MacHugh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    A predictive systems vaccinology framework enables rational optimization of MVA-based vaccines

    Vincent Deman, Philippe Castera ... Anne-Sophie Beignon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Microbiology and Infectious Disease
    2. Neuroscience

    Persistent Microglial HIV Infection Drives Neuroinflammation Despite Viral Suppression: Insights from Rapid Postmortem Brain Biopsies

    M Nühn Marieke, Nadia Sabet ... Jori Symons
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Developmental Biology

    Ectopic hAMH-driven SOX17 expression induces hyperplastic Sertoli valve formation in mouse testes

    Xiao Han, Aya Uchida ... Yoshiakira Kanai
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo

    Marie Kubota, Julia M Abitbol ... Stefan Heller
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Neuroscience

    Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

    Vincent Richter, Tilman Triphan ... Andreas S Thum
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Exceptional
    1. Physics of Living Systems

    Differential spatial regulation and activation of integrin nanoclusters inside focal adhesions

    Sarah Keary, Amaris Guevara-Garcia ... Maria F Garcia-Parajo
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Physics of Living Systems

    Sarcomere dynamic instability and stochastic heterogeneity drive robust cardiomyocyte contraction

    Daniel Haertter, Lara Hauke ... Christoph F Schmidt
    A non-monotonic force–velocity relationship in cardiac sarcomeres causes dynamic instability, leading to stochastic heterogeneity in contracting cardiomyocytes, which can have a protective function.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis

    Sage WR Geher, Seyi Falekun ... Paul A Sigala
    Malaria parasites have evolved a noncanonical function for the apicoplast acyl carrier protein in stabilizing pyruvate kinase II, a metabolic hub essential for isoprenoid synthesis and parasite survival.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Stochastic fluctuations play an important role in the MCMV-induced NK cell clonal expansion that ultimately gives rise to memory NK cells.
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