Browse the latest research

19,083 results found
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Germline-somatic residue synergy reshapes antibody encounter-state pathways to enhance HIV-1 recognition

    Sangita Kachhap, Yishak Bililign ... Rory Henderson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Chromosomes and Gene Expression
    2. Medicine

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Structural Biology and Molecular Biophysics

    Structural basis for site-specific histone H3 acetylation-dependent regulation of RNAPII transcription through nucleosomes

    Takumi Oishi, Suguru Hatazawa ... Hitoshi Kurumizaka
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Developmental Biology

    A genetic screen reveals dosage-sensitive effects of ASD genes and identifies domino as a regulator of synaptic and behavioral phenotypes

    Ellen Stirtz, Zachary B Madaj ... Adelheid Lempradl
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    A stable cryogenic fluorescence microscope for correlative super-resolution light and electron microscopy

    Soheil Mojiri, Joseph M Dobbs ... Jonas Ries
    Not revised
    Reviewed Preprint v1
    • Useful
    • Compelling
    1. Neuroscience

    Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    Brandon Williams, Riya Dahal ... John A White
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Cluster size determines internal structure of transcription factories in human cells

    Massimiliano Semeraro, Giuseppe Negro ... Davide Marenduzzo
    In a polymer model of chromatin that explicitly incorporates different types of transcription factors, both specialised and mixed factories emerge naturally, with their composition governed by their size.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics

    Bader Rayan, Eilon Barnea ... Meytal Landau
    RNA differentially regulates the assembly pathways of bacterial and host α-helical peptides, revealing supramolecular architecture as a tunable determinant of cytotoxic and antimicrobial function.
    1. Neuroscience

    The view tolerance of human identity recognition depends on horizontal face information

    Alexia Roux-Sibilon, Helene Dumont ... Valerie Goffaux
    View-tolerant identity recognition in humans depends on the stable identity cues provided by horizontal facial information.
    1. Cell Biology
    2. Neuroscience

    FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall

    Jewel T-Y Li, Mehdi Amiri ... Wayne S Sossin
    The loss of FMRP does not affect how neuronal ribosomes are stalled or where they are stalled, but reduces the number of neuronal RNA granules that contain stalled ribosomes.

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