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Synthetic adaptors combining camelid nanobodies with the UBX domain of the p97 adaptor FAF1 enable targeted substrate delivery to p97, establishing an E3 ubiquitin ligase-independent mechanism for selective protein degradation.

LIN code offers a reliable framework for classifying gonococcal population structure, enabling straightforward exploration of isolate relationships, from broad superlineage divisions to minute single allele differences.

Analysis of ~50 million articles published in ~50 thousand journals demonstrates that journals have become more diverse in terms of both interdisciplinarity and internationalization but with some disciplinary differences.

Analysis of hundreds of single-cell genomes from Yellowstone National Park shows bacterial species are less cohesive than previously thought.

A hierarchy of models guided by experimental results from zebrafish shows that coordinated, variable-speed locomotion can emerge from network-level interactions among interneuron populations with structured spatial connectivity.

By modeling the single-trial electroencephalogram of participants performing perceptual decisions, and building on predictions from two century-old psychological laws, we estimate the times of information processing steps contained in decision-making.