Controlling cell migration

Latest research

1. 1. Neuroscience

   Regional response to light illuminance across the human hypothalamus

   Islay Campbell, Roya Sharifpour ... Gilles Vandewalle
2. 1. Ecology

   Coordinated molecular and ecological adaptations underlie a highly successful parasitoid

   Lan Pang, Gangqi Fang ... Jianhua Huang
3. 1. Biochemistry and Chemical Biology

   A multi-hierarchical approach reveals d-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

   Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori

   An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
4. 1. Developmental Biology

   Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

   Amandine Jarysta, Abigail LD Tadenev ... Basile Tarchini

   Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
5. 1. Cell Biology

   Endogenous tagging using split mNeonGreen in human iPSCs for live imaging studies

   Mathieu C Husser, Nhat P Pham ... Alisa Piekny

   The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.
6. 1. Structural Biology and Molecular Biophysics

   LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

   Colin H Peters, Rohit K Singh ... John R Bankston

   A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
7. 1. Computational and Systems Biology
   2. Developmental Biology

   A logic-incorporated gene regulatory network deciphers principles in cell fate decisions

   Gang Xue, Xiaoyi Zhang ... Zhiyuan Li

   A top-down model-guided framework unveils the role of regulatory logics underlying gene regulatory networks in cell fate decisions.
8. 1. Cancer Biology

   Recording and classifying MET receptor mutations in cancers

   Célia Guérin, David Tulasne

   Classification of MET mutations allows a better understanding of sensitivity and resistance to targeted therapies used in cancer.
9. 1. Medicine

   Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

   Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown

   MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
10. 1. Genetics and Genomics
    2. Neuroscience

    Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

    Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso

    Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.