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Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan, James M Berger
10.7554/eLife.00882
A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
Anca M Farcas, Neil P Blackledge, Ian Sudbery, Hannah K Long, Joanna F McGouran, Nathan R Rose, Sheena Lee, David Sims, Andrea Cerase, Thomas W Sheahan, Haruhiko Koseki, Neil Brockdorff, Chris P Ponting, Benedikt M Kessler, Robert J Klose
10.7554/eLife.00205
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To avoid recognition by the immune system, bacteria use autolysins to trim fragments of peptidoglycans that are exposed on the bacterial cell wall.
Magda Luciana Atilano, Pedro Matos Pereira, Filipa Vaz, Maria João Catalão, Patricia Reed, Inês Ramos Grilo, Rita Gonçalves Sobral, Petros Ligoxygakis, Mariana Gomes Pinho, Sérgio Raposo Filipe
10.7554/eLife.02277
Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
Alyson Ashe, Tony Bélicard, Jérémie Le Pen, Peter Sarkies, Lise Frézal, Nicolas J Lehrbach, Marie-Anne Félix, Eric A Miska
10.7554/eLife.00994

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