Highlights

Latest research

    1. Structural Biology and Molecular Biophysics

    Structural basis for the phase separation of the chromosome passenger complex

    Nikaela W Bryan, Aamir Ali ... Ben E Black
    The utilization of hydrogen/deuterium exchange mass spectrometry reveals dynamic insights and interactions driving liquid-liquid demixing of the chromosome passenger complex.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues

    Arthur L Schneider, Rita Martins-Silva ... Nuno L Barbosa-Morais
    voyAGEr is an online platform that facilitates the exploration of age-related gene expression dynamics in human tissues, allowing users to analyse tissue- and sex-specific changes alongside donor medical histories.
    1. Neuroscience

    Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

    Harry Clark, Matthew F Nolan
    Anchoring of grid firing fields to task environments is consistent with roles specifically in path integration rather than spatial localisation in general.
    1. Neuroscience

    Neurophysiological trajectories in Alzheimer’s disease progression

    Kiwamu Kudo, Kamalini G Ranasinghe ... Srikantan S Nagarajan
    Event-based sequencing models for Alzheimer’s disease progression revealed that abnormal neural synchrony occurs during the earliest preclinical stages of the disease, preceding brain atrophy and cognitive decline.
    1. Immunology and Inflammation

    Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    T.O. Nakonechnaya, B. Moltedo ... D.M. Chudakov
    1. Cell Biology
    2. Physics of Living Systems

    Mitosis sets nuclear homeostasis of cancer cells under confinement

    Malèke Mouelhi, Alexis Saffon ... Charlotte Rivière
    1. Cell Biology

    Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

    James S. White, Jasmine J. Su ... Andrea Page-McCaw
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

    Zhenyong Wu, Grant F Kusick ... Shigeki Watanabe
    The calcium-binding proteins synaptotagmin 7 and Doc2α act sequentially during asynchronous neurotransmitter release.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.