Highlights

Latest research

    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues

    Arthur L Schneider, Rita Martins-Silva ... Nuno L Barbosa-Morais
    voyAGEr is an online platform that facilitates the exploration of age-related gene expression dynamics in human tissues, allowing users to analyse tissue- and sex-specific changes alongside donor medical histories.
    1. Immunology and Inflammation

    Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    T.O. Nakonechnaya, B. Moltedo ... D.M. Chudakov
    1. Cell Biology
    2. Physics of Living Systems

    Mitosis sets nuclear homeostasis of cancer cells under confinement

    Malèke Mouelhi, Alexis Saffon ... Charlotte Rivière
    1. Cell Biology

    Wound-Induced Syncytia Outpace Mononucleate Neighbors during Drosophila Wound Repair

    James S. White, Jasmine J. Su ... Andrea Page-McCaw
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

    Zhenyong Wu, Grant F Kusick ... Shigeki Watanabe
    The calcium-binding proteins synaptotagmin 7 and Doc2α act sequentially during asynchronous neurotransmitter release.
    1. Cancer Biology

    Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

    Wanyoung Lim, Inwoo Hwang ... Sungsu Park
    A microfluidic device induces doxorubicin-resistant polyaneuploid cancer cells from triple negative breast cancer cells, revealing NUPR1/HDAC11 axis dysfunction drives chemoresistance, increasing tumor heterogeneity and impacting clinical outcomes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
    Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
    1. Medicine

    Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

    Hong Chen, Lijun Sun ... Yue Yin
    Intermittent fasting affects intestinal immunity through new interactions between macrophages and ILC3s, increasing ILC3 secretion of IL-22 and thus promoting white adipose tissue beigeing, and improving metabolism.