mTOR signaling and autism

Latest research

1. 1. Neuroscience

   Experience transforms crossmodal object representations in the anterior temporal lobes

   Aedan Yue Li, Natalia Ladyka-Wojcik ... Morgan Barense
2. 1. Ecology

   Warming and altered precipitation independently and interactively suppress alpine soil microbial growth in a decadal-long experiment

   Yang Ruan, Ning Ling ... Zhibiao Nan

   Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
3. 1. Cancer Biology
   2. Genetics and Genomics

   Convergent epigenetic evolution drives relapse in acute myeloid leukemia

   Kevin Nuno, Armon Azizi ... Ravindra Majeti

   Integrated analyses of acute myeloid leukemia genetics and epigenetics demonstrate that epigenetic evolution occurs in a convergent manner in the absence of DNA mutations at relapse post-chemotherapy.
4. 1. Genetics and Genomics
   2. Neuroscience

   Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

   Bohan Zhu, Richard I Ainsworth ... Javier González-Maeso

   Age and antipsychotic treatment effects on chromatin organization in the frontal cortex of schizophrenia subjects.
5. 1. Medicine

   Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

   Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown

   MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
6. 1. Medicine
   2. Cancer Biology

   RGS10 deficiency facilitates distant metastasis by inducing epithelial–mesenchymal transition in breast cancer

   Yang Liu, Yi Jiang ... Xi Gu
7. 1. Biochemistry and Chemical Biology

   Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

   George N. Bendzunas, Dominic P Byrne ... Natarajan Kannan
8. 1. Microbiology and Infectious Disease
   2. Computational and Systems Biology

   Merging Multi-OMICs with Proteome Integral Solubility Alteration Unveils Antibiotic Mode of Action

   Ritwik Maity, Xuepei Zhang ... Javier Sancho
9. 1. Genetics and Genomics

   De novo variants in PLCG1 are associated with hearing impairment, ocular pathology, and cardiac defects

   Mengqi Ma, Yiming Zheng ... Hugo J. Bellen
10. 1. Cell Biology
    2. Computational and Systems Biology

    De novo-designed minibinders expand the synthetic biology sensing repertoire

    Zara Y. Weinberg, Sarah S. Soliman ... Hana El-Samad