Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Plant Biology

   Guanidine production by plant homoarginine-6-hydroxylases

   Dietmar Funck, Malte Sinn ... Jörg S Hartig

   2-Oxoglutarate and Fe(II)-dependent dioxygenases from clade C23 are the major source of guanidine in plants and release guanidine from arginine or homoarginine by C5 or C6 hydroxylation, respectively.
2. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   The rules of sex and strain: deciphering the chemical language of inbred and wild mouse conspecific scents

   Maximilian Nagel, Marco Niestroj ... Marc Spehr
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Microphase Separation Produces Interfacial Environment within Diblock Biomolecular Condensates

   Andrew P. Latham, Longchen Zhu ... Bin Zhang
4. 1. Biochemistry and Chemical Biology
   2. Medicine

   Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

   Giulia Leanza, Francesca Cannata ... Nicola Napoli

   In individuals with type 2 diabetes, downregulation of bone canonical Wnt signaling is linked to higher levels of advanced glycation end-products within the bone, contributing to lower bone strength.
5. 1. Biochemistry and Chemical Biology

   The Listeria monocytogenes persistence factor ClpL is a potent stand-alone disaggregase

   Valentin Bohl, Nele Merret Hollmann ... Axel Mogk

   The bacterial AAA+ chaperone ClpL recognizes aggregated proteins via multiple contacts of its unique N-terminal domain and refolds them with high efficiency providing superior heat resistance.
6. 1. Biochemistry and Chemical Biology

   A multi-hierarchical approach reveals D-serine as a hidden substrate of sodium-coupled monocarboxylate transporters

   Pattama Wiriyasermkul, Satomi Moriyama ... Shushi Nagamori
7. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism

   Bernd K. Gilsbach, Franz Y. Ho ... Christian Johannes Gloeckner
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

   Tien M Phan, Young C Kim ... Jeetain Mittal

   Despite highly conserved sequences, subtle variations in HP1 paralog charge distribution influence distinct liquid-liquid phase separation behaviors, ultimately impacting DNA-mediated heterochromatin organization.
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

   Ornella Bimaï, Ipsita Banerjee ... Derek T. Logan
10. 1. Biochemistry and Chemical Biology
    2. Cancer Biology

    DePARylation is critical for S phase progression and cell survival

    Litong Nie, Chao Wang ... Junjie Chen

    DePARylation is essential for cell survival and thus poly(ADP-ribose) glycohydrolase (PARG) expression correlates with cytotoxicity induced by PARG inhibition, which will benefit the development of PARG inhibitors for cancer treatment.