Biophysics and structural biology

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Experiment-driven quantitative model of IL-2 secretion demonstrates how T cells integrate their digital antigen responses into an analog-scaled output.
Karen E Tkach, Debashis Barik, Guillaume Voisinne, Nicole Malandro, Matthew M Hathorn, Jesse W Cotari, Robert Vogel, Taha Merghoub, Jedd Wolchok, Oleg Krichevsky, Grégoire Altan-Bonnet
10.7554/eLife.01944
Analysis of protein–protein encounter complexes shows that proteins associate along preferred pathways, similar to the sliding of a protein along DNA.
Dima Kozakov, Keyong Li, David R Hall, Dmitri Beglov, Jiefu Zheng, Pirooz Vakili, Ora Schueler-Furman, Ioannis Ch Paschalidis, G Marius Clore, Sandor Vajda
10.7554/eLife.01370
The Bipolar Assembly domain of kinesin-5 comprises an anti-parallel four-helix bundle, which explains how kinesin-5 subunits assemble into bipolar tetramers with two motile ends that transmit forces while crosslinking and sliding adjacent microtubules during mitosis.
Jessica E Scholey, Stanley Nithianantham, Jonathan M Scholey, Jawdat Al-Bassam
10.7554/eLife.02217
A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett
10.7554/eLife.01808
A novel innate defense mechanism of cell lysis involves the coordinated oligomerization of a defensin by interaction with the membrane lipid, phosphatidylinositol 4,5-bisphosphate.
Ivan KH Poon, Amy A Baxter, Fung T Lay, Grant D Mills, Christopher G Adda, Jennifer AE Payne, Thanh Kha Phan, Gemma F Ryan, Julie A White, Prem K Veneer, Nicole L van der Weerden, Marilyn A Anderson, Marc Kvansakul, Mark D Hulett
10.7554/eLife.01808.034

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Show10255075100rows
Showing results 1 - 10 of 108