Biophysics and structural biology

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Building on previous work (Diao et al., 2012), we show that the mechanism by which complexin suppresses spontaneous fusion is distinct from the mechanism by which it synchronizes Ca2+-triggered fusion.
Ying Lai, Jiajie Diao, Daniel J Cipriano, Yunxiang Zhang, Richard A Pfuetzner, Mark S Padolina, Axel T Brunger
10.7554/eLife.03756
‘Optical tweezers’ measurements of single ribosomes and single mRNA molecules show that the translation rate depends exponentially on the applied force, and suggests that the ribosome functions as a Brownian ratchet.
Tingting Liu, Ariel Kaplan, Lisa Alexander, Shannon Yan, Jin-Der Wen, Laura Lancaster, Charles E Wickersham, Kurt Fredrik, Harry Noller, Ignacio Tinoco, Carlos J Bustamante
10.7554/eLife.03406

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