Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics

    Structural basis for the phase separation of the chromosome passenger complex

    Nikaela W Bryan, Aamir Ali ... Ben E Black
    The utilization of hydrogen/deuterium exchange mass spectrometry reveals dynamic insights and interactions driving liquid-liquid demixing of the chromosome passenger complex.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

    Karolina Honzejkova, Dalibor Kosek ... Tomas Obsil
    Thioredoxin functions as a negative allosteric effector of ASK1 by altering the interaction between the thioredoxin-binding and tetratricopeptide repeats domains, thereby reducing access to the kinase domain's activation segment.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock

    Daniyal Tariq, Nicole Maurici ... Brian R Crane
    The intrinsic disorder of the circadian clock protein Frequency organizes binding partners, facilitates liquid–liquid phase separation, modulates Frequency phosphorylation, and derives from sequence properties conserved with homologous clock components.

Senior editors

  1. Felix Campelo
    The Institute of Photonic Sciences, Spain
  2. Qiang Cui
    Boston University, United States
  3. Volker Dötsch
    Goethe University, Germany
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