Cell biology

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In the Arabidopsis epidermis, the internal mechanical stress of a cell competes with the external stress to control microtubule behavior, providing a framework to understand the mechanical feedbacks that underlie plant morphogenesis.
Arun Sampathkumar, Pawel Krupinski, Raymond Wightman, Pascale Milani, Alexandre Berquand, Arezki Boudaoud, Olivier Hamant, Henrik Jönsson, Elliot M Meyerowitz
10.7554/eLife.01967
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LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
Jennifer L Mamrosh, Jae Man Lee, Martin Wagner, Peter J Stambrook, Richard J Whitby, Richard N Sifers, San-Pin Wu, Ming-Jer Tsai, Francesco J DeMayo, David D Moore
10.7554/eLife.01694
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Interactions between Aim24 and the mitochondrial outer and inner membrane contact site complex (MICOS) are essential for mitochondrial ultrastructure, lipid composition and oxidative phosphorylation.
Max Emanuel Harner, Ann-Katrin Unger, Toshiaki Izawa, Dirk M Walther, Cagakan Özbalci, Stefan Geimer, Fulvio Reggiori, Britta Brügger, Matthias Mann, Benedikt Westermann, Walter Neupert
10.7554/eLife.01684
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The Bipolar Assembly domain of kinesin-5 comprises an anti-parallel four-helix bundle, which explains how kinesin-5 subunits assemble into bipolar tetramers with two motile ends that transmit forces while crosslinking and sliding adjacent microtubules during mitosis.
Jessica E Scholey, Stanley Nithianantham, Jonathan M Scholey, Jawdat Al-Bassam
10.7554/eLife.02217
The same membrane trafficking cargo can change pathways mediated by different members of ARF-GEF family of vesicle formation regulators.
Sandra Richter, Marika Kientz, Sabine Brumm, Mads Eggert Nielsen, Misoon Park, Richard Gavidia, Cornelia Krause, Ute Voss, Hauke Beckmann, Ulrike Mayer, York-Dieter Stierhof, Gerd Jürgens
10.7554/eLife.02131
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