Human biology and medicine

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The microRNA, miR-146a, is regulated by mutant BRAF/NRAS proteins, and promotes the development of melanoma via increasing Notch signaling pathway, suggesting that combining drugs targeting BRAF/NRAS and Notch may provide an effective melanoma treatment.
Matteo Forloni, Shaillay Kumar Dogra, Yuying Dong, Darryl Conte Jr, Jianhong Ou, Lihua Julie Zhu, April Deng, Meera Mahalingam, Michael R Green, Narendra Wajapeyee
10.7554/eLife.01460
The transcription factor STAT5 mediates the increased breast cancer risk associated with a late age pregnancy, but intermittent anti-STAT5 treatment can lower this risk and thus prevent breast cancer.
Svasti Haricharan, Jie Dong, Sarah Hein, Jay P Reddy, Zhijun Du, Michael Toneff, Kimberly Holloway, Susan G Hilsenbeck, Shixia Huang, Rachel Atkinson, Wendy Woodward, Sonali Jindal, Virginia F Borges, Carolina Gutierrez, Hong Zhang, Pepper J Schedin, C Kent Osborne, David J Tweardy, Yi Li
10.7554/eLife.00996
Natural sugars are preferred over artificial sweeteners because of their nutritional content, which is sensed by MCH neurons in the lateral hypothalamus.
Ana I Domingos, Aylesse Sordillo, Marcelo O Dietrich, Zhong-Wu Liu, Luis A Tellez, Jake Vaynshteyn, Jozelia G Ferreira, Mats I Ekstrand, Tamas L Horvath, Ivan E de Araujo, Jeffrey M Friedman
10.7554/eLife.01462
Cells from the human pancreatic duct can be grown in culture and triggered to become insulin-producing cells, which could potentially be transplanted into patients with diabetes.
Jonghyeob Lee, Takuya Sugiyama, Yinghua Liu, Jing Wang, Xueying Gu, Ji Lei, James F Markmann, Satsuki Miyazaki, Jun-ichi Miyazaki, Gregory L Szot, Rita Bottino, Seung K Kim
10.7554/eLife.00940
The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.
Shawniqua T Williams, Mary M Conte, Andrew M Goldfine, Quentin Noirhomme, Olivia Gosseries, Marie Thonnard, Bradley Beattie, Jennifer Hersh, Douglas I Katz, Jonathan D Victor, Steven Laureys, Nicholas D Schiff
10.7554/eLife.01157
The cancer drug vemurafenib has potent off-target effects on JNK signaling that contribute to the development of squamous cell carcinomas in humans and in mice.
Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
10.7554/eLife.00969
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