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In press

Thu, 2014-02-27 16:25 -- elife

The following papers are in press with eLife.

Research Articles - due online 22/04/14

 

Gating of neural error signals during motor learning
Rhea R Kimpo, Jacob M Rinaldi, Christina K Kim, Hannah L Payne, Jennifer L Raymond
Correspondence: Jennifer L Raymond / Stanford University

Electrode recordings and optogenetics reveal that the cerebellum can modulate its response to error signals from the brainstem during motor learning.

 

GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides
Yu Zhang, David Degen, Mary X Ho, Elena Sineva, Katherine Y Ebright, Yon W Ebright, Vladimir Mekler, Hanif Vahedian-Movahed, Yu Feng, Ruiheng Yin, Steve Tuske, Herbert Irschik, Rolf Jansen, Sonia Maffioli, Stefano Donadio, Eddy Arnold, Richard H Ebright
Correspondence: Richard H Ebright / Rutgers University

The cyclic-peptide antibiotic GE23077 inhibits bacterial RNA polymerase through a novel target that exhibits low susceptibility to target-based resistance and that enables synthesis of bipartite inhibitors that are exceptionally potent and refractory to target-based resistance.
See also: Insight by Kristine B Arnvig and Finn Werner

 

SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans
Xiaoyan Guo, L René García
Correspondence: L René García / Howard Hughes Medical Institute, Texas A&M University

A protein called SIR-2.1 helps to protect worms from the effects of aging by regulating metabolic processes that would otherwise generate damaging reactive oxygen species.

 

Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development
Leonardo Gastón Guilgur, Pedro Prudêncio, Daniel Sobral, Denisa Liszekova, André Rosa, Rui Gonçalo Martinho
Correspondence: Rui Gonçalo Martinho / Instituto Gulbenkian de Ciência

The need for efficient pre-RNA splicing during early embryonic development of Drosophila indicates that the constraints imposed by the cell cycle are a force capable of driving changes in Eukaryotic gene architecture.

 

Regulation of branching dynamics by axon-intrinsic asymmetries in Tyrosine Kinase Receptor signaling
Marlen Zschätzsch, Carlos Oliva, Marion Langen, Natalie De Geest, Mehmet Neset Öze, W Ryan Williamson, William C Lemon, Alessia Soldano, Sebastian Munck, P Robin Hiesinger, Natalia Sanchez-Soriano, Bassem A Hassan
Correspondence: Bassem A Hassan / Vlaams Instituut voor Biotechnologie

Asymmetric localization of the receptor EGFR within branches of axons is required to establish the precise wiring of neuronal networks within the Drosophila brain.

 

Transgressions of compartment boundaries and cell reprogramming during regeneration inDrosophila
Salvador C Herrera, Ginés Morata
Correspondence: Ginés Morata / Universidad Autónoma de Madrid

The reconstruction of damaged structures during regeneration requires cell reprogramming mediated by the up regulation of the JNK pathway and the transient debilitation of the epigenetic control mechanism.

 

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK
Olga Ostrovskaya, Keqiang Xie, Ikuo Masuho, Ana Fajardo-Serrano, Rafael Lujan, Kevin Wickman, Kirill A Martemyanov
Correspondence: Kirill A Martemyanov / The Scripps Research Institute

A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.

 

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
Iris Jonkers, Hojoong Kwak, John T Lis
Correspondence: John T Lis / Cornell University

The elongation rate of RNA Polymerase II varies greatly between and along genes, as this enzyme accelerates from stable pausing to rapid elongation within genes, and is influenced by CG-content, exons and chromatin.

 

Insights

Antibiotics: A new spanner in the works of bacterial transcription
Kristine B Arnvig, Finn Werner

 

Editorial

Coming soon to a screen near you
Melissa Harrison

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