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In press

The following papers are in press with eLife.

Research Articles - due online 29/04/14


Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation
Andrei S Avanesov, Siming Ma, Kerry A Pierce, Sun Hee Yim, Byung Cheon Lee, Clary B Clish, Vadim N Gladyshev
Correspondence: Vadim N Gladyshev / Harvard Medical School

Aging is a process characterized by gradual metabolome remodeling, deceleration of the remodeling in late life and under conditions that extend lifespan, and a mortality-associated pattern of cumulative damage.


Symmetry breaking in reconstituted actin cortices
Enas Abu Shah, Kinneret Keren
Correspondence: Kinneret Keren / Technion–Israel Institute of Technology

A reconstituted system has been developed that self-organizes into dynamic actin cortices capable of spontaneous polarization, similar to the initial cortical polarization observed in cells during embryogenesis and development.


Repair of naturally occurring mismatches can induce mutations in flanking DNA
Jia Chen, Brendan F Miller, Anthony V Furano
Correspondence: Anthony V Furano / National Institute of Diabetes and Digestive and Kidney Diseases

The repair of spontaneous DNA damage can introduce mutators that lead to further genetic changes, which could underlie evolutionary change, disease and aging.


Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron
Frederic A Roemschied , Monika J Eberhard , Jan-Hendrik Schleimer , Bernhard Ronacher, Susanne Schreiber
Correspondence: Susanne Schreiber / Humboldt-Universität zu Berlin

Firing rate in grasshopper receptor neurons is surprisingly robust to changes in temperature and cell-intrinsic mechanisms are sufficient to account for the observed temperature compensation.


Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA
Ruobo Zhou, Jichuan Zhang, Matthew L Bochman, Virginia A Zakian, Taekjip Ha
Correspondence: Taekjip Ha / University of Illinois at Urbana-Champaign

Analyzing single molecules reveals that Pif1 family helicases periodically patrol DNA, which may explain this enzyme's ability to suppress genome instability at G-quadruplex motifs and transcriptional RNA-DNA hybrids (R-loops).
See also: Insight by Gheorghe Chistol and Johannes Walter



DNA helicases: Molecular watchdogs on genome patrol
Gheorghe Chistol, Johannes Walter


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