56 results found
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of alpha-synuclein fibrils

    Ricardo Guerrero-Ferreira, Nicholas MI Taylor ... Henning Stahlberg
    The alpha-synuclein fibril structure reported here buries residues 50-57 at the interface between its two protofilaments, suggesting that familial Parkinson's disease associated mutations in these residues lead to a structure not compatible with the one presented here.
    1. Neuroscience

    TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

    Maxime WC Rousseaux, Maria de Haro ... Huda Y Zoghbi
    Convergent screens targeting the levels of alpha-synuclein and tau identify TRIM28 as a driver of their stability, nuclear accumulation and subsequent toxicity.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy

    Ricardo Guerrero-Ferreira, Nicholas MI Taylor ... Henning Stahlberg
    Two new polymorphic structures of recombinant human alpha-synuclein fibrils show striking differences to previous structures, while familial PD mutation sites remain crucial for protofilament interaction and fibril stability.
    1. Cell Biology
    2. Neuroscience

    Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers

    Shenjie Wu, Nancy C Hernandez Villegas ... Randy Schekman
    A pathway of unconventional secretion for alpha-synuclein, a protein which may spread in the brain as part of the pathology of Parkinson’s disease.
    1. Structural Biology and Molecular Biophysics

    Molecular basis for N-terminal alpha-synuclein acetylation by human NatB

    Sunbin Deng, Buyan Pan ... Ronen Marmorstein
    The cryo-EM structure of the human N-terminal acetyltransferase NatB bound to a cognate N-terminal alpha-synuclein peptide reveals the molecular determinants of NatB-specific protein acetylation.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

    Jiajie Diao, Jacqueline Burré ... Axel T Brunger
    Experiments on synthetic models of synaptic vesicles have shed new light on the role of the protein α-synuclein in the central nervous system.
    1. Microbiology and Infectious Disease
    2. Neuroscience

    A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

    Timothy R Sampson, Collin Challis ... Sarkis K Mazmanian
    Production of an amyloid protein by bacteria within the gut microbiome can influence the pathophysiology of a mouse model of synucleinopathy.
    1. Neuroscience

    Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

    Selene Seoyun Lee, Livia Civitelli, Laura Parkkinen
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Therapeutic genetic variation revealed in diverse Hsp104 homologs

    Zachary M March, Katelyn Sweeney ... James Shorter
    Exploring natural Hsp104 variation reveals unexpected tuning of a passive activity that inhibits aggregation of specific substrates to selectively counter TDP-43 or alpha-synuclein proteotoxicity connected to neurodegenerative disease.
    1. Biochemistry and Chemical Biology

    Inhibition of synucleinopathic seeding by rationally designed inhibitors

    Smriti Sangwan, Shruti Sahay ... David S Eisenberg
    Inhibitors of seeded propagation of alpha-synuclein may be developed into diagnostics and therapeutics for Parkinson's disease.

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