8,666 results found
    1. Cell Biology

    An extensive program of periodic alternative splicing linked to cell cycle progression

    Daniel Dominguez, Yi-Hsuan Tsai ... Zefeng Wang
    Extensive periodic regulation of alternative splicing during the cell cycle in genes is linked to cell cycle functions, and involves an auto-inhibitory mechanism that uses the protein kinase CLK1.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin, Tae Wan Kim ... Hong-Duk Youn
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Cell Biology

    LINE-1 protein localization and functional dynamics during the cell cycle

    Paolo Mita, Aleksandra Wudzinska ... Jef D Boeke
    A combination of functional, biochemical and imaging studies show that LINE-1/L1 proteins and mRNA enter the nucleus through mitotic nuclear membrane breakdown, interact with components of the DNA replication fork and mediate retrotransposition during S phase.
    1. Cell Biology

    CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

    Désirée Schatton, Giada Di Pietro ... Elena I Rugarli
    CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

    Marta Perera, Silas Boye Nissen ... Joshua M Brickman
    The simultaneous expansion of G1 and acceleration of the cell cycle, while ensuring synchronous inheritance of these properties, progressively induces cell identity in differentiation.
    1. Cell Biology
    2. Computational and Systems Biology

    Multiple inputs ensure yeast cell size homeostasis during cell cycle progression

    Cecilia Garmendia-Torres, Olivier Tassy ... Gilles Charvin
    Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
    1. Computational and Systems Biology
    2. Developmental Biology

    Spatiotemporal control of cell cycle acceleration during axolotl spinal cord regeneration

    Emanuel Cura Costa, Leo Otsuki ... Osvaldo Chara
    Computational modeling and a cell cycle-reporting axolotl reveal how spinal cord regeneration can be achieved by a signal that propagates 828 μm from the injury site during the first 85 hours post-amputation.
    1. Cancer Biology

    Repurposing of KLF5 activates a cell cycle signature during the progression from a precursor state to oesophageal adenocarcinoma

    Connor Rogerson, Samuel Ogden ... Andrew D Sharrocks
    Genome-wide redistribution of KLF5 binding leads to activation of a cell cycle gene expression programme and proliferation control in oesophageal cancer.
    1. Microbiology and Infectious Disease

    Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

    Sara Marelli, James C Williamson ... Nicholas J Matheson
    Systematic screen of HIV-1 Vif mutants identifies synthetic and naturally occurring amino acid polymorphisms separating PPP2R5 and APOBEC3 family protein depletion and uncovers the mechanism of Vif-dependent cell cycle arrest.

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