569 results found
    1. Microbiology and Infectious Disease

    The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

    Anne Günther, Matthias Hose ... Wiebke Hansen
    Host cell acid ceramidase activity contributes to the regulation of erythrocyte maturation and thereby affects the frequency of target cells for rodent Plasmodium yoelii parasites.
    1. Biochemistry and Chemical Biology

    Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

    Matthijs Kol, Ben Williams ... James A Frank
    Photoswitchable ceramides containing an azobenzene photoswitch behave as light-controllable substrates for both sphingomyelin synthase and glucosylceramide synthase.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

    Alexis Diaz-Vegas, Søren Madsen ... James G Burchfield
    In vitro and in vivo studies uncovered a molecular link between elevated mitochondrial ceramide levels, coenzyme Q depletion, and insulin resistance.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis

    Karen Mendelson, Suveg Pandey ... Todd Evans
    Developing oocytes lacking Sphk2 sense high sphingosine levels and transcriptionally activate expression of the gene encoding Cers2b, to mediate a salvage pathway to reduce potentially toxic sphingosine.
    1. Cell Biology

    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling

    Stéphanie Torrino, Victor Tiroille ... Stephan Clavel
    UBTD1 coordinates EGFR signaling by modulating ceramides level through ASAH1 ubiquitination and EGFR degradation through SQSTM1/p62 ubiquitination, which together impact cell proliferation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids

    Alexander Muir, Subramaniam Ramachandran ... Jeremy Thorner
    TORC2-Ypk1 signaling upregulates flux through the sphingolipid pathway not only by increasing the supply of long-chain base precursors, but also by increasing their use in synthesizing complex sphingolipids.
    1. Immunology and Inflammation

    Cell-intrinsic ceramides determine T cell function during melanoma progression

    Matthias Hose, Anne Günther ... Wiebke Hansen
    Cell-intrinsic ceramide concentrations are involved in T cell differentiation and function.
    1. Immunology and Inflammation

    Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

    Amy L Seufert, James W Hickman ... Brooke A Napier
    Enriched dietary SFAs, specifically palmitic acid (PA), induce a broad and long-lived innate immune memory response which is harmful during disease exacerbated by inflammation, but beneficial for pathogen clearance.
    1. Neuroscience

    Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14)

    Guang Lin, Burak Tepe ... Hugo J Bellen
    Endolysosmal trafficking defects, expansion of lysosomes, elevation of ceramides, and disruption of mitochondria are root causes of INAD/PARK14.
    1. Cell Biology

    Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

    Martin Wohlwend, Pirkka-Pekka Laurila ... Johan Auwerx
    CERS1 reduction in aging skeletal muscle contributes to impaired muscle function, myogenesis and increases inflammation and fibrosis, highlighting the significance of very long chain ceramides in age-related muscle homeostasis.

Refine your results by:

Type
Research categories