Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
Copy number alteration heterogeneity exists in many shapes and forms in breast cancer genomes and single-cell genomics is a powerful tool to further our understanding of its nature and significance.
Lifestyle interventions and statins may target different components of the lipid profile, suggesting that they are not redundant strategies but could be combined for better benefits.
Stefano G Giulieri, Romain Guérillot ... Benjamin P Howden
A large-scale analysis of Staphylococcus aureus within-host evolution based on a comprehensive catalogue of bacterial genetic variation reveals an excess of genome degradation signatures in infecting strains and new genetic loci of clinically relevant adaptation.
Patrick Grossmann, Olya Stringfield ... Hugo JWL Aerts
Radiomics allows automated quantification of the radiographic phenotype of a tumor across diverse patient cohorts and is connected to the underlying molecular pathway activities, which together determine the clinical outcome.
Gillian Morven Belbin, Jacqueline Odgis ... Eimear E Kenny
A health-system embedding method for genomic discovery and clinical characterization of disease highlights the importance of documenting a wider spectrum of genetic disorders in diverse populations.
Multiple -omics approaches have provided valuable insight into the pathobiology of pediatric acute respiratory distress syndrome, and novel unbiased techniques hold promise for future discoveries.
Christopher S Thom, Madison B Wilken ... Benjamin F Voight
Body mass index and adipose distribution have opposing and broad effects on human blood trait variation by Mendelian randomization analysis, helping to clarify the complex interplay between cardiometabolic traits and hematopoiesis at the genetic level.
