200 results found
    1. Cancer Biology

    Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

    Xiangmudong Kong, Wensheng Yan ... Xinbin Chen
    Mouse model reveals that TAp73γ functions as an oncogene to promote tumorigenesis and alter lipid metabolism by modulating leptin expression.
    1. Ecology
    2. Evolutionary Biology

    Effects of domestication on the gut microbiota parallel those of human industrialization

    Aspen T Reese, Katia S Chadaideh ... Rachel N Carmody
    Gut microbial signatures of domestication parallel those of industrialization, implicating shared ecological drivers.
    1. Neuroscience

    The presynaptic ribbon maintains vesicle populations at the hair cell afferent fiber synapse

    Lars Becker, Michael E Schnee ... Anthony J Ricci
    The auditory hair cell synaptic ribbon maintains vesicle pools near release sites in order to support sustained and timed vesicle release.
    1. Neuroscience

    Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders

    Xiangling Meng, Wei Wang ... Huda Y Zoghbi
    Excitatory signaling impairment contributes to neurological deficits shared by Rett syndrome and a number of postnatal neuropsychiatric disorders.
    1. Neuroscience

    Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome

    Kerstin Ure, Hui Lu ... Huda Y Zoghbi
    Genetically restoring Mecp2 expression only in GABAergic neurons in a mouse model of Rett syndrome improves inhibitory signaling, extends lifespan and rescues most but not all behavioral deficits.
    1. Microbiology and Infectious Disease

    Cohabiting family members share microbiota with one another and with their dogs

    Se Jin Song, Christian Lauber ... Rob Knight
    Research on humans and dogs reveals that the communities of microorganisms found on the skin, on the tongue and in the intestine are affected differently by age and cohabitation.
    1. Cell Biology
    2. Neuroscience

    The synaptic ribbon is critical for sound encoding at high rates and with temporal precision

    Philippe Jean, David Lopez de la Morena ... Tobias Moser
    The synaptic ribbon regulates calcium channel clustering and proper vesicle dynamics at cochlear inner hair cells to ensure precise sound encoding.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde, Carlos Eduardo G Amorim ... Christopher N Anderson
    Hypothetical battles between animals can be used to interest the general public in biology.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs

    Mingyue Chen, Yanli Lyu ... Yipeng Sun
    During adaptation in dogs, H3N2 canine influenza viruses (CIVs) became to recognize human-like SAα2,6-Gal receptor, increased replication ability in human cells, acquired a 100% transmission rate via respiratory droplet in ferret model, and human population lacked immunity to H3N2 CIVs.
    1. Evolutionary Biology

    Zooanthroponotic transmission of SARS-CoV-2 and host-specific viral mutations revealed by genome-wide phylogenetic analysis

    Sana Naderi, Peter E Chen ... B Jesse Shapiro
    Several different mutations in the SARS-CoV-2 genome have occurred more times than expected by chance in either mink or deer infections, suggesting species-specific viral adaptations to these animals.

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