17,769 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

    Christopher John Schlicksup, Joseph Che-Yen Wang ... Adam Zlotnick
    Small molecule antivirals that drive assembly of HBV capsid protein can also bind to pre-assembled capsids causing them to change morphology or even break, suggesting a complex transduction of binding effects across the capsid.
    1. Cancer Biology

    Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme

    Guillaume Jacquemin, Annabelle Wurmser ... Silvia Fre
    Studies of organoid morphogenesis, combined with proteomics and molecular profiling, identify the THBS1-YAP axis as a signalling mechanism that mediates paracrine communication between tumour cells and their wildtype epithelial neighbours.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Hepatitis C virus exploits cyclophilin A to evade PKR

    Che C Colpitts, Sophie Ridewood ... Greg J Towers
    Hepatitis C virus evades IRF1-dependent intrinsic antiviral immunity by exploiting cyclophilin A and its regulation of PKR.
    1. Immunology and Inflammation

    p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

    Hui Che, Jie Li ... Yongxin Ren
    A novel IVDD mechanism that involves p16 is demonstrated and theoretical evidence is provided for effective methods to downregulate p16 and so reverse IVDD.
    1. Cell Biology
    2. Computational and Systems Biology

    Spatially coordinated dynamic gene transcription in living pituitary tissue

    Karen Featherstone, Kirsty Hey ... Julian RE Davis
    Quantitative statistical modelling reveals local coordination of stochastic gene transcription dynamics in pituitary tissue, which is relevant for integrated tissue responses to physiological stimuli.
    1. Epidemiology and Global Health
    2. Medicine

    Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19

    Katelyn Gostic, Ana CR Gomez ... James O Lloyd-Smith
    Even in the best-case scenario, screening for COVID-19 misses well over half of infected travellers.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Coordinated hedgehog signaling induces new hair follicles in adult skin

    Xiaoyan Sun, Alexandra Are ... Maria Kasper
    Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.
    1. Chromosomes and Gene Expression

    Condensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation

    William S Kruesi, Leighton J Core ... Barbara J Meyer
    C. elegans equalizes the expression of X-chromosome genes between the sexes by reducing the recruitment of RNA polymerase II to promoters of X-linked genes in hermaphrodites, using a chromosome-restructuring complex called condensin.
    1. Biochemistry and Chemical Biology

    Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

    Rajendra Uprety, Tao Che ... Susruta Majumdar
    The structure-based design established a new approach to control pathway-selective activation of opioid receptors, resulting in new dual MOR/KOR G-protein biased agonist analgesics with attenuated liabilities.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein

    Hisham M Dokainish, Suyong Re ... Yuji Sugita
    Computer simulations explore the experimentally unknown S-protein structures, revealing novel drug binding sites.

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