1,262 results found
    1. Neuroscience

    Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice

    Yuji Okamoto, Noa Lipstein ... Mitsuharu Midorikawa
    Capacitance measurements and pH imaging reveal distinct modes of uptake for endocytotic presynaptic membrane and proteins.
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi, John JE Chua ... Dominika Czernik
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.
    1. Cell Biology

    Selective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes

    Konrad Lang, Julian Milosavljevic ... Tobias Hermle
    To maintain the filtration barrier, slit diaphragms are cleansed by rapid cycles of raft-mediated endocytosis, while dynamin-dependent endocytosis prevents lateral diffusion of slit diaphragm protein.
    1. Cell Biology

    Rapid adaptation of endocytosis, exocytosis, and eisosomes after an acute increase in membrane tension in yeast cells

    Joël Lemière, Yuan Ren, Julien Berro
    Within minutes after an abrupt increase in membrane tension, yeast cells reduce their membrane tension by modulating their rate of endocytosis and exocytosis, and adapt their endocytic actin machinery.
    1. Cell Biology

    Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

    Alenka Guček, Nikhil R Gandasi ... Sebastian Barg
    Live cell imaging shows that the cAMP-sensor Epac2, a target of major antidiabetic drugs, is central to fusion pore control during insulin granule exocytosis.
    1. Neuroscience

    Optical detection of three modes of endocytosis at hippocampal synapses

    Natali L Chanaday, Ege T Kavalali
    Single synaptic vesicle imaging shows that kinetically distinct endocytic pathways are differentially regulated by calcium and temperature, and influence the fidelity of synaptic vesicle protein retrieval.
    1. Cell Biology
    2. Neuroscience

    TRPM7 is critical for short-term synaptic depression by regulating synaptic vesicle endocytosis

    Zhong-Jiao Jiang, Wenping Li ... Liang-Wei Gong
    Electrophysiological and live-cell imaging analyses identify a presynaptic function of Ca2+ influx via transient receptor potential melastatin 7 (TRPM7) channels.
    1. Cell Biology

    Surface-associated antigen induces permeabilization of primary mouse B-cells and lysosome exocytosis facilitating antigen uptake and presentation to T-cells

    Fernando Y Maeda, Jurriaan JH van Haaren ... Wenxia Song
    The strength by which mouse B-cells bind surface-associated antigen determines how much their plasma membrane is permeabilized and also the extent of a resealing response involving lysosomal exocytosis, which promotes antigen extraction for intracellular processing and T-cell presentation.
    1. Neuroscience

    Endocytosis at the Drosophila blood–brain barrier as a function for sleep

    Gregory Artiushin, Shirley L Zhang ... Amita Sehgal
    Endocytosis through the Drosophila blood–brain barrier influences and depends upon sleep.
    1. Cell Biology
    2. Computational and Systems Biology

    DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

    Xinxin Wang, Zhiming Chen ... Gaudenz Danuser
    A new user-intervention-free classification, using single-fluorescent markers, measures conventionally unmeasureable phenotypes in early stages during clathrin-mediated endocytosis.

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