11,310 results found
    1. Ecology
    2. Evolutionary Biology

    Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

    Aditya Mahadevan, Michael T Pearce, Daniel S Fisher
    Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

    Katherine A Donovan, Jian An ... Eric S Fischer
    Thalidomide and its derivates induce degradation of many C2H2 zinc-finger transcription factors, including SALL4, providing insight into a long-standing mystery in modern pharmacology, and starting points for future drug development.
    1. Ecology
    2. Microbiology and Infectious Disease

    Metabolite exchange between microbiome members produces compounds that influence Drosophila behavior

    Caleb N Fischer, Eric P Trautman ... Nichole A Broderick
    Interactions between fungal and bacterial microbiome members alter Drosophila melanogaster's chemical environment, affecting host behavior and survival.
    1. Physics of Living Systems

    Dynamics of immune memory and learning in bacterial communities

    Madeleine Bonsma-Fisher, Sidhartha Goyal
    Bacterial CRISPR immunity tracks phage mutations, creating immune diversity in bacterial populations that parallels phage genetic diversity and patterns of phage evolution that are determined by the type and degree of immune cross-reactivity in the CRISPR system.
    1. Neuroscience

    Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition

    Petra Fischer, Alek Pogosyan ... Huiling Tan
    Sudden stopping of rhythmic movement is associated with a pronounced increase of 60-90 Hz gamma oscillations in the subthalamic nucleus, which have formerly been regarded as favouring movement.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere

    Gemma LM Fisher, César L Pastrana ... Mark S Dillingham
    A combination of structural, biochemical, single-molecule and in vivo methods are used to show how ParB locally condenses the bacterial chromosome near the origin and earmarks this region for segregation.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

    Margaret AM Nelson, Kelsey L McLaughlin ... Kelsey H Fisher-Wellman
    Across a physiological span of ATP-free energy, leukemic mitochondria primarily consume, rather than produce, ATP.
    1. Neuroscience

    Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing

    Leena Ali Ibrahim, Brie Wamsley ... Gordon Fishell
    RNA sequencing and conditional Nova mutants reveal that Nova protein function is necessary for activity-dependent alternative splicing of synaptic genes within somatostatin cortical interneurons and regulates its afferent and efferent connectivity.
    1. Ecology
    2. Evolutionary Biology

    Thermal acclimation of tropical coral reef fishes to global heat waves

    Jacob L Johansen, Lauren E Nadler ... Jodie Rummer
    The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Remote immune processes revealed by immune-derived circulating cell-free DNA

    Ilana Fox-Fisher, Sheina Piyanzin ... Yuval Dor
    Cell-free DNA methylation markers allow monitoring of immune and inflammatory cell turnover.

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