5,198 results found
    1. Cell Biology
    2. Developmental Biology

    Osteocytes regulate senescence of bone and bone marrow

    Peng Ding, Chuan Gao ... Junjie Gao
    Partial ablation of osteocytes alters lineage cell specifications in bone and bone marrow, resulting in the acceleration of skeletal aging.
    1. Microbiology and Infectious Disease

    Transcriptional regulation of SARS-CoV-2 receptor ACE2 by SP1

    Hui Han, Rong-Hua Luo ... Cheng-Gang Zou
    SP1 serves as an important transcription factor in the regulation of ACE2 expression.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy, Simon Schafer ... Fred H Gage
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Stem Cells and Regenerative Medicine

    Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

    Yixuan Wang, Chengchen Zhao ... Shaorong Gao
    During reprogramming of human fibroblasts to naïve iPSCs there is transient reactivation of transcripts with the characteristics of 8-cell-stage-embryos.
    1. Neuroscience

    anTraX, a software package for high-throughput video tracking of color-tagged insects

    Asaf Gal, Jonathan Saragosti, Daniel JC Kronauer
    anTraX is an algorithm and software package that facilitates automated analyses of insect social behavior in species and experimental settings that are not accessible with currently existing technology.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

    Zhi Yang Tan, Shujun Cai ... Lu Gan
    Nucleosomes inside of baker’s yeast cells largely do not resemble those found in test tubes.
    1. Developmental Biology
    2. Genetics and Genomics

    Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos

    Theodora Koromila, Fan Gao ... Angelike Stathopoulos
    The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Limited role of generation time changes in driving the evolution of the mutation spectrum in humans

    Ziyue Gao, Yulin Zhang ... Priya Moorjani
    A new framework for mutation spectrum analysis reveals multiple independent changes in the germline mutation patterns of human populations, which cannot be explained by shifts in average ages at reproduction.
    1. Developmental Biology

    Ancient origin of lubricated joints in bony vertebrates

    Amjad Askary, Joanna Smeeton ... J Gage Crump
    Zebrafish have lubricated joints similar to ours and are a tractable model for arthritis research.
    1. Developmental Biology

    Etv transcription factors functionally diverge from their upstream FGF signaling in lens development

    Ankur Garg, Abdul Hannan ... Xin Zhang
    The FGF-induced Etv transcription factors operate outside the confines of upstream signaling in lens development.

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