1,777 results found
    1. Immunology and Inflammation

    Notch and TLR signaling coordinate monocyte cell fate and inflammation

    Jaba Gamrekelashvili, Tamar Kapanadze ... Florian P Limbourg
    Notch signaling alters TLR-induced inflammation by skewing monocyte cell fate toward patrolling monocyte differentiation at the expense of macrophage cell fate.
    1. Cancer Biology

    Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

    Tim DD Somerville, Giulia Biffi ... Christopher R Vakoc
    A major consequence of ductal-to-squamous lineage transition in pancreatic cancer cells is to augment inflammation, which may explain the exceptionally poor clinical outcomes of squamous-subtype tumors.
    1. Cell Biology

    Age-related islet inflammation marks the proliferative decline of pancreatic beta-cells in zebrafish

    Sharan Janjuha, Sumeet Pal Singh ... Nikolay Ninov
    During aging, the pancreatic endocrine islets undergo chronic inflammation, which is associated with a reduced capacity for self-renewal of the insulin-producing beta-cells in zebrafish.
    1. Cell Biology
    2. Immunology and Inflammation

    Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling

    Brian Czaya, Kylie Heitman ... Christian Faul
    Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.
    1. Cell Biology

    Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

    King Faisal Yambire, Christine Rostosky ... Nuno Raimundo
    Impaired lysosomal acidification results in retention of iron inside lysosomes, triggering functional iron deficiency, dysfunctional mitochondria (especially mtDNA loss), and inflammation in vivo in a mouse model of lysosomal disease.
    1. Cancer Biology

    Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

    Kathryn Eaton, Ali Pirani ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced some parts of the original paper but it also contains results that are not consistent with other parts of the original paper.
    1. Immunology and Inflammation

    Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation

    Jaime James, Yifei Chen ... Rikard Holmdahl
    PTPN22 function is regulated by reactive oxygen species, and redox regulation of PTPN22 impacts T-cell-dependent autoimmune inflammation.
    1. Developmental Biology
    2. Medicine

    β-Catenin-NF-κB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

    Shikai Hu, Jacquelyn O Russell ... Satdarshan P Monga
    Ductular reaction often observed in chronic liver pathologies such as in cystic fibrosis could be due to disruption of a novel complex of β-catenin-NF-κB and CFTR in cholangiocytes, which leads to persistent nuclear translocation of p65 and NF-κB activation.
    1. Cell Biology

    LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation

    Chan Hee J Choi, William Barr ... Paul Cohen
    Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Inflammation drives alternative first exon usage to regulate immune genes including a novel iron-regulated isoform of Aim2

    Elektra K Robinson, Pratibha Jagannatha ... Susan Carpenter
    Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.

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