2,244 results found
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens, Thaleia Papadopoulou ... Pablo Navarro
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder, Shabaz Mohammed, Francis A Barr
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions

    Matthew P Miller, Elçin Ünal ... Angelika Amon
    Preventing premature interactions between microtubules and protein-based structures called kinetochores ensures that chromosomes are segregated by meiosis rather than mitosis in reproductive cells.
    1. Cell Biology

    Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation

    Claudia Pellacani, Elisabetta Bucciarelli ... Maria Patrizia Somma
    Extensive cytological and biochemical analyses show that the conserved Sf3A2 and Prp31 splicing factors bind microtubules and the Ndc80 complex, playing direct mitotic functions in both Drosophila and human mitosis.
    1. Cell Biology

    Mammalian cell growth dynamics in mitosis

    Teemu P Miettinen, Joon Ho Kang ... Scott R Manalis
    High-resolution single-cell mass accumulation and protein synthesis rate measurements are used to quantify the extent, dynamics and consequences of animal cell growth in mitosis and cytokinesis.
    1. Cancer Biology
    2. Cell Biology

    Mitosis can drive cell cannibalism through entosis

    Joanne Durgan, Yun-Yu Tseng ... Oliver Florey
    Mitosis is found to act as a novel trigger for epithelial cell cannibalism, revealing an important link between cell division and death, of relevance to cancer and chemotherapy.
    1. Cell Biology
    2. Computational and Systems Biology

    Regulation of mRNA translation during mitosis

    Marvin E Tanenbaum, Noam Stern-Ginossar ... Ronald D Vale
    Ribosomal profiling reveals that translational repression is an important mechanism for cell cycle control and can complement protein degradation.
    1. Cell Biology

    Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

    Marco Novais-Cruz, Maria Alba Abad ... Cristina Ferrás
    Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

    Tony Ly, Arlene Whigham ... Angus I Lamond
    A detailed analysis of protein abundance and phosphorylation changes across mitotic subphases and interphase in asynchronously growing human cells has been enabled by combining FACS with quantitative MS-based proteomics.
    1. Chromosomes and Gene Expression

    The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
    The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.

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