828 results found
  1. Research: Financial costs and personal consequences of research misconduct resulting in retracted publications

    Andrew M Stern, Arturo Casadevall ... Ferric C Fang
    In the first study attempting to formally quantify the deleterious impact of research misconduct on funding sources and publication output, we found that misconduct accounts for a small but substantial portion of American biomedical science funding dollars and damages the productivity and rate of funding acquisition of those who commit misconduct.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

    Marina Theodosiou, Moritz Widmaier ... Reinhard Fässler
    Kindlin-2 co-operates with talin to activate fibronectin-binding integrins on fibroblasts and subsequently induces cell spreading by recruiting paxillin to small, peripheral nascent adhesions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

    Giuseppina Mastrototaro, Pierluigi Carullo ... Marie-Louise Bang
    FHOD1 and CARP/Ankrd1 interact with the N-terminal region of palladin and cardiomyocyte-specific deletion of palladin in adult, but not embryonic, mice leads to dilated cardiomyopathy associated with intercalated disc widening.
    1. Microbiology and Infectious Disease

    Research Culture: Co-reviewing and ghostwriting by early-career researchers in the peer review of manuscripts

    Gary S McDowell, John D Knutsen ... Rebeccah S Lijek
    Early career researchers commonly peer review manuscripts on behalf of invited reviewers, often without receiving feedback or being named to the journal.
    1. Cell Biology
    2. Immunology and Inflammation

    CD31 signaling promotes the detachment at the uropod of extravasating neutrophils allowing their migration to sites of inflammation

    Francesco Andreata, Marc Clément ... Giuseppina Caligiuri
    CD31 plays a pivotal role in neutrophil migration to inflamed sites by localizing to the uropod and promoting effective actin/integrin polarization and detachment, shedding light on the molecular mechanisms underlying extravasation and inflammation response.
    1. Epidemiology and Global Health
    2. Medicine

    Science Forum: Best practices to promote rigor and reproducibility in the era of sex-inclusive research

    Janet W Rich-Edwards, Donna L Maney
    Guidelines are presented to help researchers comply with sex-inclusive research mandates while upholding high standards of rigor.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

    John Huddleston, John R Barnes ... Trevor Bedford
    The combination of phenotypic measures of antigenic drift and genotypic measures of functional constraint improves the accuracy of long-term seasonal influenza A/H3N2 forecasts.
    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic, Amanda Capes-Davis ... Anita E Bandrowski
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
  2. Meta-Research: Systemic racial disparities in funding rates at the National Science Foundation

    Christine Yifeng Chen, Sara S Kahanamoku ... Justin Hosbey
    White principal investigators applying to the National Science Foundation are consistently funded at higher rates than most non-white PIs.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.

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