1,650 results found
    1. Cell Biology

    Differential axonal trafficking of Neuropeptide Y-, LAMP1-, and RAB7-tagged organelles in vivo

    Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
    In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
    1. Genetics and Genomics

    Human genetic analyses of organelles highlight the nucleus in age-related trait heritability

    Rahul Gupta, Konrad J Karczewski ... Vamsi K Mootha
    Although cellular organelles show a functional deterioration in aging, genetic loci associated with common age-associated disease instead nominate nuclear transcription factors across several age-related diseases.
    1. Cell Biology
    2. Computational and Systems Biology

    Evaluation of predictions of the stochastic model of organelle production based on exact distributions

    C Jeremy Craven
    A reanalysis of the stochastic model of organelle production (Mukherji and O'Shea, 2014) suggests that this model requires significant further discussion.
    1. Cell Biology

    Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance

    Shankar Mukherji, Erin K O'Shea
    A systematic comparison of experimentally measured and theoretically predicted magnitudes of organelle abundance fluctuations suggests that budding yeast produces the maximum level of variability in organelle abundance that can be generated by organelle biogenesis pathways.
    1. Biochemistry and Chemical Biology

    Modular metabolite assembly in Caenorhabditis elegans depends on carboxylesterases and formation of lysosome-related organelles

    Henry H Le, Chester JJ Wrobel ... Frank C Schroeder
    Caenorhabditis elegans homologs of carboxylesterases that localize to intestinal organelles orchestrate the assembly of modular signaling molecules from building blocks that integrate diverse metabolic pathways.
    1. Cell Biology

    Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

    Yong Yu, Shihong M Gao ... Meng C Wang
    First systemic lysosomal proteomes in association with longevity and tissue specificity in C. elegans uncover lysosomal heterogeneity across multiple scales and provide valuable resources for understanding how lysosomes modulate signal transduction, organelle communication, tissue physiology, and organism longevity.
    1. Cell Biology

    Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins

    Chanjae Lee, Rachael M Cox ... John B Wallingford
    DynAPs are liquid-like organelles that are partitioned into functional sub-domains.
    1. Genetics and Genomics
    2. Plant Biology

    Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome

    Bindu Joseph, Jason A Corwin ... Daniel J Kliebenstein
    Genes located within cellular organelles impact phenotype more than expected due to their interactions with nuclear genes.
    1. Neuroscience

    Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia

    Alexis Bédécarrats, Laura Puygrenier ... Romuald Nargeot
    An atypical neuronal pacemaker mechanism triggers feeding motor pattern in Aplysia..
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Large protein organelles form a new iron sequestration system with high storage capacity

    Tobias W Giessen, Benjamin J Orlando ... Pamela A Silver
    An alternative iron storage system based on a 9.6 megadalton microbial protein compartment is able to sequester and store large amounts of iron.

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