Adjusting key parameters of the synaptic transmission at a single defined synapse of the visual circuit can affect properties of this circuit and animal behavior.

Atomic details on structural organization and conformational dynamics of the key regulator of neuronal signaling shed light on its allosteric regulation and role in regulating cellular pathways.

A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.

Increasing cortical plasticity leads to better one-trial memory but more interference effects on semantic-like memory.

New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.

Rgs12 protein is a novel regulator of the Nrf2 protein by facilitating the proteasomal degradation of the transcription factor during osteoclast differentiation.

Introducing a hominoid-specific gene into mice induces cortical folding.

A G protein in striatal neurons forms preassembled complexes with its downstream enzyme, adenylyl cyclase, which has implications for the pathophysiology of movement disorders.

Analyses based on the mouse model of a human genetic disease reveal that the neuron production of cerebral tissue can be boosted by escalated signaling between neural progenitors and the vasculature.

The dual role of Drosophila Mitofusin in steroid hormone production and cholesterol ester storage, which is evolutionary conserved by the combined expression of the two mammalian Mitofusins, ensures proper synaptic development.