1,526 results found
    1. Biochemistry and Chemical Biology

    Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

    Sarah K Stumper, Harini Ravi ... Jeff Gelles
    Single-molecule observations reveal a mechanism that may be used by multiple competing regulatory proteins to control ribosomal RNA production during rapid bacterial cell growth.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of RNA polymerase bound to ribosomal 30S subunit

    Gabriel Demo, Aviram Rasouly ... Andrei A Korostelev
    Cryo-EM structures of the 30S*RNAP complex visualize co-localization of the transcription and translation machineries and provide insights into the transcription-translation synchrony, which coordinates gene expression in bacteria.
    1. Cell Biology
    2. Immunology and Inflammation

    Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

    Xiao-Dong Li, Zhijian J Chen
    A pattern recognition receptor called toll-like receptor 13 detects pathogens in a manner that is different to that seen in other pathogen sensors.
    1. Biochemistry and Chemical Biology

    LARP4 mRNA codon-tRNA match contributes to LARP4 activity for ribosomal protein mRNA poly(A) tail length protection

    Sandy Mattijssen, Aneeshkumar G Arimbasseri ... Richard J Maraia
    The messenger RNA encoding La-related protein-4 (LARP4) contains a short region of instability whose codon clusters are sensitive to low abundance tRNAs that when elevated increase LARP4 activity for poly(A) lengthening of ribosomal protein mRNAs and other mRNAs.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges

    Libin Liu, Paul F Pilch
    PTRF (Cavin-1) mediates metabolism-regulated ribosomal transcription in mature adipocytes, independent of its role in caveolae formation.
    1. Microbiology and Infectious Disease

    Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

    Cassandra Koh, Lionel Frangeul ... Maria-Carla Saleh
    A score-based read selection strategy enables the assembly of novel full-length ribosomal RNA sequences for mosquitoes, which improves the physical and computational removal of interfering ribosomal RNA reads in RNA-seq and provides another molecular marker for taxonomic and phylogenetic inquiries.
    1. Cell Biology
    2. Computational and Systems Biology

    Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis

    Julie Paxman, Zhen Zhou ... Nan Hao
    The interaction between rDNA instability and proteostasis stress, two major aging hallmarks, underlies single-cell aging trajectories in yeast.
    1. Structural Biology and Molecular Biophysics

    Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

    Jiyun Chen, Hong Chen ... Liang Liu
    The structures of full-length Las1-Grc3 complexes provide crucial insights into the activation mechanism of HEPN nuclease and the pathway of pre-rRNA processing in ribosome biosynthesis.
    1. Cell Biology

    Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

    Yubing Liu, Wei Zou ... Xiaochen Wang
    Embryonic development requires autophagy-dependent degradation of ribosomal RNAs.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Dedicated chaperones coordinate co-translational regulation of ribosomal protein production with ribosome assembly to preserve proteostasis

    Benjamin Pillet, Alfonso Méndez-Godoy ... Dieter Kressler
    A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

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