Lizbeth Sayavedra, Manuel Kleiner ... Jillian M Petersen
Beneficial symbiotic bacteria encode an exceptional number of toxin-related genes that are all expressed by the symbionts in the host, supporting their key role in host-microbe interactions.
Genetic and microscopy analyses identify a programmed cell death mechanism that kills a cell subpopulation in a bacterial biofilm where oxygen is limiting, thereby promoting dispersion of newborn motile cells through the action of DNA released by dead cells.
The learning rate for novel spatial environments in model networks of place cells is determined by the product of the window for plasticity and the auto-correlation of place-cell activity.
Sara Masachis, Nicolas J Tourasse ... Fabien Darfeuille
A genetic selection of toxicity suppressors coupled to high-throughput sequencing has captured metastable RNA structures that co-transcriptionally inhibit the translation of a bacterial toxin.
Dagmara Korona, Benedict Dirnberger ... Kathryn S Lilley
Blocking of the function of neurotransmitter receptors by insecticidal peptide toxins resulted in identification of nicotinic acetylcholine receptor subunits through native ligand-binding investigations.
Marcos H de Moraes, FoSheng Hsu ... Joseph D Mougous
Interbacterial interactions can promote mutagenesis, and possibly adaptation, when intoxicated cells survive exposure to type VI secretion-delivered DNA deaminase toxins.
Mambalgin1 binds to the thumb domain of human ASIC1a channel and inhibits the channel through hindering the proton-induced transitions from the resting closed state to the active and/or desensitized state.
John C Whitney, S Brook Peterson ... Joseph D Mougous
Diverse LXG toxins delivered by the Esx pathway function as mediators of contact-dependent interbacterial antagonism within and between Gram-positive bacterial species.