Lentiviral protein transduction offers a new approach for administration of custom-designed nucleases, leading to high-efficacy targeted gene editing and reduced off-target activity after virus-directed delivery of programmable nuclease proteins.

A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.

Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.

Single molecule DNA-binding trajectories and deterministic modeling analyses demonstrate a functional role for high energy partly folded states in Transcription Activator-Like Effectors that could improve future TALEN design.

Elucidating the molecular mechanism by which the Hippo signaling effector Yorkie (Yki) functions as a transcriptional coactivator in growth control reveals the importance of a histone-modifying enzyme for this process.

Stem-cell-specific transcriptional repressors fine-tune levels of stemness gene transcripts in asymmetrically dividing neural stem cells by depositing low levels of repressive histone marks at these loci allowing progeny to rapidly initiate differentiation.

Transcription factors KLF2 and ETV1 repress the transcriptional program of mitochondrial biogenesis, resulting in impaired mitochondrial function in lysosomal storage diseases.

Switches in cell state downstream of pathogen exposure are driven by a deeply conserved disorder-to-order phase transition in an immunity signaling network.