1,450 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

    Hari B Kamadurai, Yu Qiu ... Brenda A Schulman
    Structural studies reveal the mechanism by which a HECT E3 ubiquitin ligase carries out E2-to-E3-to-substrate ubiquitin transfer and prioritizes target lysines for ubiquitination.
    1. Genetics and Genomics

    Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

    Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
    Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.
    1. Biochemistry and Chemical Biology

    The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains

    Alan Rodriguez Carvajal, Irina Grishkovskaya ... Fumiyo Ikeda
    The E3 ubiquitin ligase complex linear ubiquitin chain assembly complex (LUBAC) forms a branched chain on linear ubiquitin chains depending on the RING-in-between-RING-type E3 ligase heme-oxidized IRP2 ubiquitin ligase 1 (HOIL-1L).
    1. Stem Cells and Regenerative Medicine

    The CUL4-DDB1 ubiquitin ligase complex controls adult and embryonic stem cell differentiation and homeostasis

    Jie Gao, Shannon M Buckley ... Iannis Aifantis
    DDB1, a component of the ubiquitin proteasome system, plays a role in both hematopoietic and embryonic stem cell self-renewal and differentiation.
    1. Structural Biology and Molecular Biophysics

    A conformational switch regulates the ubiquitin ligase HUWE1

    Bodo Sander, Wenshan Xu ... Sonja Lorenz
    The cancer-associated human ubiquitin ligase HUWE1 can adopt an auto-inhibited dimeric state, whose occupancy is regulated by competing intra- and intermolecular interactions of the dimerization region and by the tumor suppressor p14ARF.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech, Federica Lari ... John C Christianson
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Developmental Biology
    2. Neuroscience

    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

    Chien-Hsiang Wang, Yi-Chun Huang ... Cheng-Ting Chien
    Maintenance of ubiquitin homeostasis is essential for proper control of the size of postsynaptic density and the growth of specialized membrane structure.
    1. Biochemistry and Chemical Biology

    A cryptic K48 ubiquitin chain binding site on UCH37 is required for its role in proteasomal degradation

    Jiale Du, Sandor Babik ... Eric Strieter
    The proteasomal deubiquitinase UCHL5/UCH37 uses a face distinct from the canonical ubiquitin binding site to engage K48-linked ubiquitin chains and catalyze chain debranching.
    1. Structural Biology and Molecular Biophysics

    Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

    Zhu Liu, Zhou Gong ... Chun Tang
    Lys63-linked diubiquitin exists as an ensemble of conformational states, each responsible for binding to a target protein through conformational selection.
    1. Cell Biology

    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

    Nathaniel L Hepowit, Kevin N Pereira ... Jason A MacGurn
    Ser57 phosphorylation of ubiquitin protects the cell during proteotoxic stress.
    Short Report Updated
    Formats available:
    • HTML
    • PDF

Refine your results by:

Type
Research categories