Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Epidermal resident memory T cell fitness requires antigen encounter in the skin

   Eric S Weiss, Toshiro Hirai ... Daniel H Kaplan

   Antigen-driven TCR signaling in the epidermis during CD8⁺ T_RM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal T_RM fitness.
2. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients

   Chuansong Quan, Lu Wang ... Haifeng Hou

   Increased fucosylated IgG and reduced bisecting GlcNAc during HTNV convalescence may promote rapid recovery from hemorrhagic fever with renal syndrome.
3. 1. Immunology and Inflammation

   Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

   Conan JO O'Brien, Giorgio Ratti ... Ana I Domingos

   Loss of class A scavenger receptor MARCO results in elevated lung Ace expression and elevated plasma aldosterone concentrations in male mice, demonstrating an endocrine function of this immune scavenger receptor.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Phospholipid scramblase 1 (PLSCR1) regulates interferon-lambda receptor 1 (IFN-λR1) and IFN-λ signaling in influenza A virus (IAV) infection

   Alina Xiaoyu Yang, Lisa Ramos-Rodriguez ... Yang Zhou

   PLSCR1 is an IFN-λ-stimulated gene that enhances IFN-λR1 expression at both transcriptional and protein level, highlighting the potential for targeting PLSCR1 pathways in anti-influenza therapy.
5. 1. Immunology and Inflammation

   Trained Immunity: RoadMap for drug discovery and development

   Jelmer H van Puffelen, Callum Campbell ... Pauline T Lukey

   Combining scientific rigour and drug development experience to map out a route to novel treatments for Trained Immunity-dependent diseases.
6. 1. Immunology and Inflammation

   Thymic self-recognition-mediated TCR signal strength modulates antigen- specific CD8⁺ T cell pathogenicity in non-obese diabetic mice

   Chia-Lo Ho, Li-Tzu Yeh ... Huey-Kang Sytwu
7. 1. Immunology and Inflammation

   A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology

   Michaela Reichmann, Liku B Tezera ... Paul Elkington
8. 1. Immunology and Inflammation

   Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

   Sabelo Hadebe, Anca Flavia Savulescu ... Frank Brombacher

   Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.
9. 1. Immunology and Inflammation
   2. Stem Cells and Regenerative Medicine

   IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

   Daniel L Aldridge, Zachary Lanzar ... Christopher A Hunter

   Functional analyses showcase that in the absence of IL-27, hematopoietic stem and progenitor cells are more likely to become monocytes during toxoplasmosis, making them less responsive after infection.
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A modular platform to display multiple hemagglutinin subtypes on a single immunogen

    Dana Thornlow Lamson, Faez Amokrane Nait Mohamed ... Aaron G Schmidt

    BOAS is a platform for building multivalent viral protein immunogens without a scaffold, such as a nanoparticle, to elicit broad influenza vaccine responses.