Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   An IL-21R hypomorph circumvents functional redundancy to define STAT1 signaling in germinal center responses

   Christoph Jandl, Joanna Warren ... Cecile King
2. 1. Immunology and Inflammation

   A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

   Yuji Miyatake, Takeshi Kamakura ... Ai Kotani

   Mir195 enables Ebf1-deficient hematopoietic progenitor cells to mature into B cells, suggesting some miRNA can substitute for transcription factors in differentiation.
3. 1. Immunology and Inflammation

   Ly6G⁺ granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

   Priya Sharma, Raman Deep Sharma ... Dhiraj Kumar

   The IL-17–Ly6G⁺ granulocyte axis is a key driver and correlate of tuberculosis pathology and represents a potential target for improving vaccine-induced protection and therapeutic outcomes.
4. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

   Ozkan Aydemir, Jeffrey A Bailey ... TEDDY Study Group

   HLA-DRA intronic haplotype associates with opposite effects on type 1 diabetes and celiac disease, refining genetic risk prediction and implicating complement genes C4A and C4B in divergent autoimmune pathways.
5. 1. Immunology and Inflammation

   Single-cell transcriptomics identifies altered neutrophil dynamics and accentuated T-cell cytotoxicity in tobacco-flavored e-cigarette-exposed mouse lungs

   Gagandeep Kaur, Thomas Lamb ... Irfan Rahman

   Profiling cell-specific immune responses reveals altered neutrophil function and enhanced T-cell mediated cell death following acute in vivo exposure to tobacco-flavored e-cigarette aerosol using single-cell technology.
6. 1. Immunology and Inflammation
   2. Neuroscience

   Microglia replacement by ER-Hoxb8 conditionally immortalized macrophages provides insight into Aicardi–Goutières syndrome neuropathology

   Kelsey M Nemec, Genevieve Uy ... F Chris Bennett

   A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

   Pien Margien van Paassen, Alexander O Pasternak ... Godelieve J de Bree

   In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ T-cells at 24 weeks of therapy predicted the subsequent reduction in the viral reservoir.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Doubling dolutegravir dosage reduces the viral reservoir in ART-treated people with HIV

   Céline Fombellida-Lopez, Aurelija Valaitienė ... Gilles Darcis

   In a randomized trial, ART intensification by doubling the dolutegravir dosage in people with HIV stably suppressed on dolutegravir-based ART reduced levels of four HIV reservoir markers in peripheral blood.
9. 1. Immunology and Inflammation

   Western lifestyle linked to maladaptive trained immunity

   Aurelia Josephine Merbecks, Christabel Mennicken ... Eicke Latz

   Trained immunity enhances innate immune responses, yet a Western lifestyle may lead to maladaptive trained immunity and drive non-communicable diseases.
10. 1. Immunology and Inflammation
    2. Neuroscience

    Trained immunity in acute and chronic neurological diseases

    Sijia Zhang, Arthur Liesz

    Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation across neurological diseases, offering new insights into disease mechanisms and potential therapeutic strategies.