Immunology and Inflammation

Immunology and Inflammation

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

    Jacob S Dearborn, Luke Frankiw ... Devdoot Majumdar
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Immunology and Inflammation

    Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency

    Eliezer Heller, Lucas dos Santos Dias, Michail S Lionakis
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation

    Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

    Christopher Zhe Wei Lee, Farah Tasnim ... Florent Ginhoux
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    GM-CSF regulates ILC states and myeloid cell signaling during ulceration in Crohn’s disease

    Joshua K Morrison, Ksenija Sabic ... Ling-shiang Chuang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation

    B cell expression of an enzymatic intermediary in ether lipid biosynthesis promotes antibody responses and germinal center size

    Sung Hoon Cho, Marissa A Jones ... Mark R Boothby
    Genetic experiments combined with cellular and biochemical analyses including lipidomics performed by imaging mass spectrometry reveal that the capacity of mature B lymphocytes and germinal center B cells to synthesize some ether phospholipids is vital for normal humoral responses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Redirection of SARS-CoV-2 to Phagocytes by Intranasal sACE2-Fc as a Universal Decoy Confers Complete Prophylactic Protection

    Jingyi Wang, Jiangchuan Li ... Bo Feng
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Immunology and Inflammation

    HEB collaborates with TCR signaling to upregulate Id3 and enable γδT17 cell maturation in the fetal thymus

    Johanna S Selvaratnam, Juliana DB da Rocha ... Michele Kay Anderson
    Dynamic regulation of the E-protein/Id axis links TCR signaling to the maturation of IL-17-producing γδ T cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Clathrin-independent endocytosis and retrograde transport in cancer cells tune immune synapse organization and CD8 T cell response

    Shiqiang Xu, Alix Buridant ... Henri-François Renard
    Endophilin-A3-mediated clathrin-independent endocytosis and retrograde trafficking in cancer cells regulate ICAM1 organization at the immune synapse and influence cytotoxic CD8 T cell response.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    The long non-coding RNA Dreg1 is required for optimal ILC2 development

    Sara Quon, Adelynn Tang ... Rhys S Allan
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Antibody Language Models: Taking the biology seriously makes models better

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    A new biologically-informed training paradigm enables protein language models to predict affinity maturation trajectories for antibodies.
    Version of Record
    Insight
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Highlights

    1. Evolutionary Biology
    2. Immunology and Inflammation

    Language models for antibodies

    Antonio Matas-Gil, Andreas Tiffeau-Mayer
    1. Immunology and Inflammation
    2. Neuroscience

    Microglia: Replacing the immune system of the brain

    Julie Rebejac, Soyon Hong
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  2. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Research Center for Advanced Science and Technology, The University of Tokyo, Japan
  3. Aleksandra Walczak
    Ecole Normale Superieure, France
  4. See more editors