Highlights

  • Getting ready to open

    Clusters of synapses develop in the primary visual cortex in young mice before they open their eyes for the first time.

    Alexandra H. Leighton, Juliette E. Cheyne, Christian Lohmann
    Reviewed Preprint Updated
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    From July 1, the fee for Reviewed Preprints will increase from $2,000 to $2,500 to support sustainability of our publishing.

    Inside eLife
  • Decoding spike signatures

    Nuclei cells in the cerebellum produce distinct spike signatures for ataxia, dystonia, and tremor in mouse models.

    Meike E. van der Heijden, Amanda M. Brown ... Roy V. Sillitoe
    Reviewed Preprint Updated

Latest research

    1. Neuroscience

    A fear conditioned cue orchestrates a suite of behaviors in rats

    Amanda Chu, Nicholas T Gordon ... Michael A McDannald
    Comprehensive behavioral ethograms reveal a fear conditioned cue to elicit a temporally organized suite of behaviors spanning freezing, locomotion, rearing, and jumping.
    1. Cancer Biology
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    CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake

    Savvas Nikolaou, Amelie Juin ... Laura M Machesky
    Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.
    1. Cell Biology

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    Rachel Pudlowski, Lingyi Xu ... Jennifer T. Wang
    1. Neuroscience

    Chronic activation of a negative engram induces behavioral and cellular abnormalities

    Alexandra L. Jellinger, Rebecca L. Suthard ... Steve Ramirez
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    Neural Trajectories of Conceptually Related Events

    Matthew Schafer, Philip Kamilar-Britt ... Daniela Schiller
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling

    Samuel C Griffiths, Jia Tan ... Hsin-Yi Henry Ho
    Structure-function analysis of the ROR2 cysteine-rich domain reveals a new mechanism of WNT5A reception at the cell surface and provides new insights into the pathogenic mechanisms of Robinow syndrome-driving ROR2 mutations.