Biochemistry and Chemical Biology

Latest articles

1. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Melanophilin mediates the association of myosin-5a with melanosome via three distinct interactions

   Jiabin Pan, Rui Zhou ... Xiang-dong Li
2. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity

   Xiaolin Yu, Guangfei Duan ... Shi-Zhong Luo
3. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural and dynamic changes in P-Rex1 upon activation by PIP₃ and inhibition by IP₄

   Sandeep K. Ravala, Sendi Rafael Adame-Garcia ... John J. G. Tesmer
4. 1. Biochemistry and Chemical Biology
   2. Cell Biology

   Remodeling of skeletal muscle myosin metabolic states in hibernating mammals

   Christopher TA Lewis, Elise G Melhedegaard ... Julien Ochala

   During hibernation, animals remodel the structure of their relaxed muscle via a protein called myosin and this enables vast temperature changes.
5. 1. Biochemistry and Chemical Biology
   2. Microbiology and Infectious Disease

   Hyperglycemia-induced cathepsin L maturation: Linking to diabetic comorbidities and COVID-19 mortality

   Qiong He, Miao-Miao Zhao ... Jin-Kui Yang
6. 1. Biochemistry and Chemical Biology
   2. Neuroscience

   Deciphering the chemical language of inbred and wild mouse conspecific scents

   Maximilian Nagel, Marco Niestroj ... Marc Spehr

   Parallel chemical and physiological profiling of conspecific chemosensory communication in mice identifies both common and unique strategies for vomeronasal signaling of sex and strain.
7. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Caenorhabditis elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA

   Claudia D Consalvo, Adedeji M Aderounmu ... Brenda L Bass

   Biochemical and structural analyses unravel how two RIG-I-like helicases function together to promote antiviral defense and illustrates the diverse ways innate immunity evolved.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors

   Damien M Rasmussen, Manny M Semonis ... Nicholas M Levinson

   A comprehensive allosteric model describes how inhibitors can activate rather than inhibit a target kinase by selectively driving formation of kinase dimers with one inhibited and one activated subunit.
9. 1. Biochemistry and Chemical Biology
   2. Developmental Biology

   Non-autonomous cell redox-pairs dictate niche homeostasis in multi-lineage stem populations

   Olivia Majhi, Aishwarya Chhatre ... Devanjan Sinha
10. 1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages

    Timothy A Bates, Mila Trank-Greene ... Fikadu G Tafesse