• Getting to grips with touch

    Experiments on duck cells reveal how forces on the skin are converted into electrical signals in sensory neurons. Photo: Bagriantsev Laboratory

    Luke H Ziolkowski, Elena O Gracheva, Sviatoslav N Bagriantsev
    Short Report Updated
  • Brain injury and aging

    Studies of transcription reveal how traumatic brain injury and aging influence cell composition and gene expression in the meninges.

    Ashley C Bolte, Daniel A Shapiro ... John R Lukens
    Tools and Resources
  • eLife Board of Directors

    eLife is pleased to welcome four new members to its Board of Directors, which helps to direct the organization in its mission to transform research communication.

    Inside eLife

Latest research

    1. Medicine

    Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: from experimental discovery to validation in two independent patient cohorts

    Richard C Lauer, Marc Barry ... Wadih Arap
    PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.
    1. Developmental Biology

    Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

    Florian Schueder, Pierre Mangeol ... Frank Schnorrer
    The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
    1. Developmental Biology

    A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

    Vincent Loreau, Renate Rees ... Dirk Görlich
    A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.
    1. Cell Biology
    2. Neuroscience

    Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

    Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens
    Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
    1. Physics of Living Systems

    Geometric control of Myosin-II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

    Mary F Fontana, Erica Ollmann Saphire, Marion Pepper
    Flow cytometric analysis of antigen-specific B and T cell responses to heterologous immunization reveals intact dendritic cell function, but selective defects in germinal center formation, in mice with concurrent malaria.
    1. Cell Biology
    2. Neuroscience

    Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant

    Alessandro Dema, Rabab A Charafeddine ... Torsten Wittmann