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Latest research

    1. Neuroscience

    The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin

    Hemin Feng et al.
    Cholecystokinin-positive neural projection from entorhinal cortex to lateral amygdala modulates the long-term potentiation of auditory-evoked potential in lateral amygdala and underlies the formation of trace fear memory.
    1. Medicine

    Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling

    Joseph D Butner et al.
    A mechanistic mathematical model informed by standard‐of‐care imaging and pathology predicts tumor responses to immunotherapy a priori on a per-patient basis.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A computational screen for alternative genetic codes in over 250,000 genomes

    Yekaterina Shulgina, Sean R Eddy
    Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions

    Jasmin Mertins et al.
    SNARE–SNARE interactions that have previously only been proposed to participate in membrane fusion on the nanoscale also serve to organize SNARE domains on the mesoscale.