Browse our latest research

Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.

Endolysosmal trafficking defects, expansion of lysosomes, elevation of ceramides, and disruption of mitochondria are root causes of INAD/PARK14.

Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.

Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.

Hepatocytes proliferate to maintain a constant liver-to-body mass ratio during intermittent fasting.

The eggshells of palaeognath birds (e.g. ostrich, moa, kiwi, emu) have diverse homology and convergent features, and are useful modern analogues for the evolution of non-avian dinosaur eggshells.

Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.

The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.

PRUNE2/PCA3 axis dysregulation is an early, rather than late, event in prostate cancer tumorigenesis.

The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.