Slam is an outer membrane protein translocon that functions with the periplasmic chaperone Skp to translocate protein substrates across the outer membrane of Gram-negative cells.
The redox reagent dithiothreitol causes toxicity by depleting S-adenosylmethionine levels, and dietary vitamin B12 could alleviate this toxicity via the methionine synthase enzyme.
Ceereena Ubaida-Mohien, Sally Spendiff ... Russell T Hepple
Skeletal muscle from world-class octogenarian athletes, representing a population with very high physical function in advanced age, exhibits greater mass and strength that is associated with overrepresentation of proteins involved in mitochondrial biology and more oxidatively competent muscle fibers.
Larisa Venkova, Amit Singh Vishen ... Matthieu Piel
Whether deforming cells behave as elastic balls (deforming at constant volume) or as sponges (loosing volume as they deform) depends on how fast they change their shape, because the cell volume depends on the tension of the plasma membrane.
Laura Jones, Madeleine Verriotis ... Maria Fitzgerald
Widespread somatosensory cortical activation following a single localised skin breaking procedure indicates a diffuse pain map in the human infant brain.
Toby Mansell, Richard Saffery ... Barwon Infant Study Investigator Group
More parent-reported infections in the first year of life were associated with metabolic differences linked with cardiovascular and metabolic disease in adulthood, with observational evidence for inflammation partly mediating this relationship.
A high-resolution approach for monitoring dry mass and the density of that dry mass on a single-cell level is developed and used to reveal that mammalian cells can lose components in mitosis due to lysosomal exocytosis.
Henning Tiedemann, Yaniv Morgenstern ... Roland W Fleming
Humans are able to generate a complete category of varied objects from just one exemplar shape, identifying and utilizing its most distinctive parts to create a coherent group, even for other observers.
Mathematical modelling and large-scale online experiments revealed that learning from others can induce 'smarter' decisions even when most individuals are biased towards adverse risk aversion.
Daisuke Nakane, Gen Enomoto ... Takayuki Nishizaka
Colour-controlled c-di-GMP signalling mediates directional switch of phototaxis via within-a-pole regulation of type IV pili in rod-shaped cyanobacteria Thermosynechococcus vulcanus.
