Adishesh K Narahari, Alex JB Kreutzberger ... Douglas A Bayliss
Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.
Emx2 is not required for sibling HCs to acquire their designated locations within the neuromast, inferring that Emx2 mediates opposite HC orientation by changing location of hair bundle establishment.
Whereas SARS-CoV-2 utilizes cathepsins to enter most cell lines, human airway organoids revealed that entry into relevant cells is dependent on serine proteases, which can be targeted for treatment.
Salah A Baker, Wesley A Leigh ... Kenton M Sanders
An optogenetic dual-color Ca2+-imaging approach shows how submucosal pacemaker-cells, interstitial cells of Cajal, modulate smooth-muscle responses and drive colonic motility via complex Ca2+ signaling.
The gustatory receptor PxylGr34 is tuned to the steroid plant hormone brassinolide and mediates the deterrent effects of brassinolide on feeding and ovipositing behaviors in Plutella xylostella.
Jack Alfred Bryant, Faye C Morris ... Ian R Henderson
Analysis of the E. coli protein DolP reveals the first dual BON-domain structure and identifies phospholipid binding as a new mechanism for protein localisation to the outer membrane division site.
Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
For perceptual inference, human observers do not estimate sensory uncertainty instantaneously from the current sensory signals alone, but by combining past and current sensory inputs consistent with a Bayesian learner.
