Browse our latest research

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    1. Chromosomes and Gene Expression

    Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

    Mark C Johnson, Geylani Can ... Philip Zegerman
    The S-phase checkpoint has roles in all phases of the cell cycle, which has implications for the majority of cancers that lack cell cycle controls.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Mixed cytomegalovirus genotypes in HIV-positive mothers show compartmentalization and distinct patterns of transmission to infants

    Juanita Pang, Jennifer A Slyker ... Judith Breuer
    Genomic analyses provide new insights into natural history and pathogenesis of cytomegalovirus infection and suggest new testable hypotheses that could be important for the design and implementation of new vaccines.
    1. Neuroscience

    Oxytocin modulates human chemosensory decoding of sex in a dose-dependent manner

    Kepu Chen, Yuting Ye ... Wen Zhou
    Oxytocin, but not the structurally similar vasopressin, modulates both the chemosensory decoding of femininity in straight men and that of masculinity in gay men in an inverted-U-shaped manner.
    1. Immunology and Inflammation

    Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses

    Risa Ebina-Shibuya, Erin E West ... Warren J Leonard
    Immunological analysis of wild-type and Crlf2-/- mice reveals a role for the cytokine thymic stromal lymphopoietin on memory CD8+ T-cell responses to viral infection, findings with potential translational implications.
    1. Neuroscience

    Longitudinal stability of medial temporal lobe connectivity is associated with tau-related memory decline

    Quanjing Chen, Adam Turnbull ... Feng V Lin
    Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.
    1. Stem Cells and Regenerative Medicine

    Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells

    John P Russell, Xinhong Lim ... Cynthia L Andoniadou
    Stem cells of the pituitary gland contribute to organ growth cell non-autonomously by promoting proliferation of committed progenitors through WNT ligand secretion.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Spatial correlations constrain cellular lifespan and pattern formation in corneal epithelium homeostasis

    Lior Strinkovsky, Evgeny Havkin ... Yonatan Savir
    Rejuvenation of corneal epithelium in homeostasis is determined by the interplay between corneal cells replicative lifespan and the spatial correlation between cell replication and cell removal.
    1. Medicine

    The gut microbiota is a transmissible determinant of skeletal maturation

    Abdul Malik Tyagi, Trevor M Darby ... Roberto Pacifici
    The gut microbiota is a non-genomic, transmissible regulator of bone volume, structure, and turnover.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation

    E Fabian Cardozo-Ojeda, Elizabeth R Duke ... Joshua T Schiffer
    Mathematical models reveal the conditions required for long-term HIV remission using autologous transplantation of hematopoietic stem cells.
    1. Evolutionary Biology

    Determining the probability of hemiplasy in the presence of incomplete lineage sorting and introgression

    Mark S Hibbins, Matthew JS Gibson, Matthew W Hahn
    Introgression makes hemiplasy more likely, and the probability of hemiplasy incorporating incomplete lineage sorting (ILS) and introgression can be estimated using the presented simulation software.