• Cylicins and male fertility

    Mutations in the genes for two cytoskeletal proteins found in sperm, Cylicin 1 and Cylicin 2, can lead to infertility in mice and humans.

    Simon Schneider, Andjela Kovacevic ... Hubert Schorle
    Research Article
  • The ins and outs of breathing

    Subpopulations of neurons in the pre-Bötzinger complex coordinate breathing with a range of physiological behaviors.

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    Research Article Updated
  • Memory and multiple sclerosis

    A new approach to measuring visual working memory has revealed fresh insights into the origins of memory deficit in multiple sclerosis. (Photo: Pouria Motaghi CC-BY)

    Ali Motahharynia, Ahmad Pourmohammadi ... Mehdi Sanayei
    Research Article

Latest research

    1. Cell Biology

    Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes

    Xiang Wang, Vitaliy V Bondar ... Anastasia G Henry
    Rab12 was identified as a key modulator of LRRK2-dependent Rab phosphorylation that mediates the recruitment of LRRK2 to lysosomes in response to damage.
    Short Report Updated
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    1. Cell Biology

    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase

    Herschel S Dhekne, Francesca Tonelli ... Suzanne R Pfeffer
    Activating mutations in the leucine-rich repeat kinase 2 cause Parkinson’s disease, and an unbiased genome-wide screen revealed an unexpected, specific role for Rab12 in activating this kinase directly for Rab GTPase phosphorylation.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Evolution towards simplicity in bacterial small heat shock protein system

    Piotr Karaś, Klaudia Kochanowicz ... Krzysztof Liberek
    Phylogenetic and biochemical analysis reveals crucial role of two substitutions in the α–crystallin domain for development of new functionality of IbpA chaperone after the loss of paralogous IbpB in Erwiniaceae.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK

    William Matlock, Samuel Lipworth ... REHAB Consortium
    A geographically and temporally restricted genomic surveillance study concludes that Enterobacterales plasmid dissemination between human and non-human niches might be occurring at greater rates than previously estimated.
    1. Neuroscience

    ACC neural ensemble dynamics are structured by strategy prevalence

    Mikhail Proskurin, Maxim Manakov, Alla Karpova
    Anterior Cingulate Cortex displays robust tracking during strategy execution of a summary statistic for that strategy in recent behavioral history, suggesting a role for this brain region in estimating which actions promote the occurrence of events in the environment.
    1. Cell Biology

    Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    Ling-Yun Zhou, Chen-Xi Jin ... Hao Wu
    In hair cells, the development and maintenance of the F-actin-enriched stereocilia and cuticular plates are differentially regulated by transcription factors SRF and MRTFB, and SRF–CNN2 is required for modulating actin dynamics of the stereocilia and cuticular plate.
    1. Neuroscience

    Behavioral entrainment to rhythmic auditory stimulation can be modulated by tACS depending on the electrical stimulation field properties

    Yuranny Cabral-Calderin, Daniela van Hinsberg ... Molly J. Henry