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Latest research

    1. Developmental Biology
    2. Genetics and Genomics

    Using population selection and sequencing to characterize natural variation of starvation resistance in Caenorhabditis elegans

    Amy K Webster et al.
    A powerful sequencing approach is used to elucidate the genetic basis of a complex organismal trait, and members of the irld gene family that affect starvation resistance are identified.
    1. Immunology and Inflammation

    Efferocytosis of SARS-CoV-2-infected dying cells impairs macrophage anti-inflammatory functions and clearance of apoptotic cells

    Ana CG Salina et al.
    Internalization of apoptotic SARS-CoV-2 infected cells leads to proinflammatory macrophage activation and reduction in macrophage capacity to perform further efferocytosis.
    1. Neuroscience

    Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

    Ryan S Phillips et al.
    The predictive power of a computational model advances understanding of the neuronal and circuit biophysical mechanisms that generate the respiratory rhythm and neural activity patterns in the mammalian brainstem.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum

    Thiery Masserey et al.
    Models of malaria and treatment dynamics were combined with emulator-based global sensitivity analysis to elucidate the interplay between drug, biology, and epidemiological factors on the evolution of resistance to malaria treatments, including artemisinin.
    1. Cell Biology
    2. Developmental Biology

    Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation

    Jaclyn Camuglia et al.
    Morphogenetic forces from tissue invagination orient cell division through a previously undescribed mechanism of force-dependent LGN/Pins polarization.
    1. Medicine

    Insights from full-text analyses of the Journal of the American Medical Association and the New England Journal of Medicine

    Moustafa Abdalla et al.
    Historical analysis of nearly half-a-million articles from the Journal of the American Medical Association and the New England Journal of Medicine since their inception frames the shifting scientific, material, ethical, and epistemic underpinnings of medicine over time, including today.