eLife is an open-access journal that publishes promising research in the life and biomedical sciences

Latest research

    1. Cancer Biology

    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Xiaochuan Shan et al
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
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    1. Biochemistry
    2. Cell Biology

    Affimers proteins are versatile and renewable affinity reagents

    Christian Tiede et al.
    The Affimer technology represents renewable binding reagents for molecular biology, which provides research scientists and industry with an alternative to the recently criticised use of animal-produced antibodies.
    Tools and Resources
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    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Poly(A) tail length regulates PABPC1 expression to tune translation in the heart

    Sandip Chorghade et al
    A poly(A) tail-based regulatory mechanism dynamically controls PABPC1 protein synthesis in cardiomyocytes and thereby titrates cellular translation in response to developmental and hypertrophic cues.
    Research Article
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    1. Biochemistry
    2. Cancer Biology

    Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

    Megan Reed Showalter et al.
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    Replication Study
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Lineage commitment of embryonic cells involves MEK1-dependent clearance of pluripotency regulator Ventx2

    Pierluigi Scerbo et al.
    Degradation and asymmetric inheritance during cell division of a core pluripotency regulator contributes to lineage commitment in the early Xenopus embryo.
    Research Article
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    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of influenza across multiple spatiotemporal scales

    Katherine S Xue et al
    Influenza evolution within infected hosts recapitulates many evolutionary dynamics observed at the global scale.
    Short Report
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    1. Microbiology and Infectious Disease

    Rv3723/LucA coordinates fatty acid and cholesterol uptake in Mycobacterium tuberculosis

    Evgeniya V Nazarova et al
    The integral membrane protein LucA facilitates fatty acid and cholesterol uptake into Mycobacterium tuberculosis by stabilizing the Mce1 and Mce4 transporters, respectively, and Mce1 functions as a fatty acid transporter in Mycobacterium tuberculosis.
    Research Article
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