Editors for Genes and Chromosomes

The working scientists who serve as eLife editors, our early-career advisors, governing board, and our executive staff all work in concert to realise eLife’s mission to accelerate discovery

Senior editors

  1. James Manley

    Senior Editor

    James Manley received a BS from Columbia University, a PhD from Stony Brook/Cold Spring Harbor Labs, and did postdoctoral work at MIT. He has been in the Department of Biological Sciences at Columbia University since 1980, was Chair from 1995–2001, and Julian Clarence Levi Professor of Life Sciences since 1995. His research interests center on understanding the mechanisms and regulation of gene expression in eukaryotes, especially with regard to mRNA splicing and 3’ end formation; how these processes are linked to transcription, cell signaling pathways, and maintenance of genomic stability; and how they contribute to cell differentiation and disease. He has authored or coauthored nearly 300 research articles and reviews on these topics, and is an ISI Highly Cited Researcher. Dr. Manley is a Fellow of the American Academy of Microbiology, the American Academy of Arts and Sciences, and the American Association for the Advancement of Science, and a member of the National Academy of Sciences.

    Expertise
    Genes and Chromosomes
    Research focus
    chromosomes and gene expression
    transcription
    RNA processing
    translation
    RNA localization and turnover
  2. Kevin Struhl

    Senior Editor

    Kevin Struhl received a BS and MS from MIT, a PhD from Stanford University Medical School, and did postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge, UK. He has been in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School since 1982, was acting Chair from 1997–98, and has been the David Wesley Gaiser Professor since 1991. His research combines genetic, molecular, genomic, and evolutionary approaches to address a wide variety of fundamental questions about transcriptional regulatory mechanisms and chromatin structure in yeast. In addition, he is interested in elucidating transcriptional regulatory circuits that mediate the process of cellular transformation and the formation of cancer stem cells. He has authored or co-authored nearly 300 research articles and reviews, and is an ISI Highly Cited Researcher. He received the Eli Lilly Award in Microbiology and is a Distinguished Researcher at the Institute of Molecular Biology and Biotechnology in Crete. Dr. Struhl is a Fellow of the American Academy of Microbiology, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the National Academy of Sciences, and the National Academy of Medicine.

    Expertise
    Cancer Biology
    Genes and Chromosomes
    Research focus
    transcription mechanisms
    gene regulation
    chromatin
    mRNA decay
    biological function
    cellular transformation
    cancer stem cells
  3. Jessica Tyler

    Senior Editor

    Jessica Tyler was born in England in 1969. After graduating from the University of Sheffield with a Bachelors degree and the Hans Krebs Prize in Biochemistry, she performed her PhD studies at the MRC Virology Unit in Glasgow, Scotland. During her postdoctoral studies with Dr James Kadonaga at the University of California, San Diego, she identified the key chromatin assembly factors Anti-silencing Function 1 (Asf1) and characterized Chromatin Assembly Factor 1 (CAF-1) from Drosophila. In 2000, Dr Tyler started her first faculty position in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine, Denver, USA. In the next 10 years, Dr Tyler revealed that chromatin assembly and disassembly not only regulates S phase events, but also gene expression and the DNA damage response. Dr Tyler was a Leukemia and Lymphoma Society Scholar and was awarded the Charlotte Friend Woman in Cancer Research Award for 2009 from the American Association of Cancer Research (AACR). Having risen rapidly to the rank of full professor at the University of Colorado, Dr Tyler moved in 2010 to the Department of Biochemistry and Molecular Biology at MD Anderson Cancer Center in Houston. Her recent work has extended to the broader influence of chromatin assembly on mitosis, aging and cancer. She is now in the Department of Epigenetics and Molecular Carcinogenesis, where she co-directs the Center for Cancer Epigenetics and holds the Edward Rotan Distinguished Professorship in Cancer Research. Her most proud achievement is being mother to 11 year-old triplets. In November 2015, she became a Professor in the Department of Pathology and Laboratory Medicine at Weill Cornell Medical College in New York.

    Expertise
    Genes and Chromosomes
    Research focus
    epigenetic regulation
    chromatin
    gene expression
    mitosis
    aging
    cancer
  4. K VijayRaghavan

    K VijayRaghavan

    Senior Editor

    Vijay’s research aims to understand motor- and olfactory- circuit assembly: from deciphering how each component is made, interacts, and stabilises into functioning in the animal to allow behaviour in the real world. Related to the development of network function is its maintenance in the mature animal; another aspect of the work in the laboratory addresses how mature neurons and muscles are maintained. The laboratory uses a genetic approach, mainly using the fruit fly but also collaborating with those using mouse and cell-culture. VijayRaghavan is Secretary to the Government of India in the Ministry of Science and Technology in the Department of Biotechnology. He temporarily holds additional charge of the Department of Biotechnology. VijayRaghavan’s research continues at the National Centre for Biological Sciences (NCBS) of the Tata Institute of Fundamental Research (TIFR) in Bangalore, India, where he is Distinguished Professor. He studied engineering at the Indian Institute of Technology, Kanpur. His doctoral work was at TIFR, Mumbai and postdoctoral work at the California Institute of Technology. VijayRaghavan is a Fellow of the Royal Society, a Foreign Associate of the US National Academy of Sciences and a Foreign Associate of the European Molecular Biology Organization.

    Expertise
    Developmental Biology and Stem Cells
    Genes and Chromosomes
    Neuroscience
    Research focus
    genetics and genomics
    developmental biology
    neurogenetics
    neurobiology
    genetic basis of behavior

Reviewing editors

  1. Kavitha Sarma

    Wistar Institute, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    epigenetics
    chromatin
    noncoding RNA
    Experimental organism
    human
    mouse
  2. Abby Dernburg

    University of California, Berkeley, United States

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    meiosis
    synapsis
    meiotic recombination
    chromosome dynamics
    Experimental organism
    C. elegans
  3. Raymund Wellinger

    Université de Sherbrooke, Canada

    Expertise
    Genes and Chromosomes
    Research focus
    telomere replication
    telomere biology
    telomerase
    DNA replication
    genomics of yeast
    Experimental organism
    S. cerevisiae
  4. Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    Expertise
    Genes and Chromosomes
    Research focus
    DNA replication
    chromatin replication
    chromosome segregation
    Experimental organism
    human
    S. cerevisiae
  5. A. Thomas Look

    Dana-Farber Cancer Institute, United States

    Expertise
    Cancer Biology
    Genes and Chromosomes
    Human Biology and Medicine
    Research focus
    neuroblastoma
    acute leukemia
    hematopoietic malignancies
    cancer genetics
    Experimental organism
    human
    mouse
    zebrafish
  6. Matt Kaeberlein

    University of Washington, United States

    Expertise
    Genes and Chromosomes
    Research focus
    aging
    longevity
    mitochondria
    proteostasis
    Experimental organism
    Yeast
    C. elegans
    mouse
    Dog
  7. Elçin Ünal

    University of California, Berkeley, United States

    Expertise
    Genes and Chromosomes
    Research focus
    gametogenesis
    aging
    age-induced cellular damage
    meiotic chromosome segregation
    Experimental organism
    S. cerevisiae
    C. elegans
  8. Karen Adelman

    Harvard Medical School, United States

    Expertise
    Genes and Chromosomes
    Research focus
    chromatin structure
    gene expression
    transcription
  9. Andres Aguilera

    University of Seville, Spain

    Expertise
    Genes and Chromosomes
    Research focus
    genome instability
    recombinational DNA repair
    R loops
    transcription-replication conflicts
    Experimental organism
    C. elegans
    S. cerevisiae
  10. Julie Ahringer

    Cambridge University, United Kingdom

    Expertise
    Developmental Biology and Stem Cells
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    cell fate
    gene expression
    chromatin biology
    epigenetics
    Experimental organism
    C. elegans
  11. Asifa Akhtar

    Max Planck Institute for Immunobiology and Epigenetics, Germany

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    gene expression
    chromatin biology
    epigenetics
    transcription
    Experimental organism
    Drosophila
  12. Richard Amasino

    University of Wisconsin, United States

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Plant Biology
    Research focus
    plant development and epigenetics
    Experimental organism
    arabidopsis thaliana
    brachypodium distachyon
  13. David Baulcombe

    Cambridge University, United Kingdom

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Plant Biology
    Research focus
    epigenetics
    RNA silencing
    plant microbe interactions and signaling
    Experimental organism
    arabidopsis thaliana
  14. Douglas L Black

    University of California, Los Angeles, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    pre-mRNA splicing
    post-transcriptional gene regulation
  15. Benjamin J Blencowe

    University of Toronto, Canada

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    RNA processing
    epigenomics
    transcriptome analyses
  16. Michael R Botchan

    University of California, Berkeley, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    DNA replication
    DNA repair
    Experimental organism
    Drosophila
  17. Irwin Davidson

    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS/INSERM/UDS, France

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Genes and Chromosomes
    Research focus
    transcription
    chromatin
    cancer
  18. Roger Davis

    University of Massachusetts Medical School, United States

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    signal transduction
  19. Bernard de Massy

    Institute of Human Genetics, CNRS, France

    Expertise
    Genes and Chromosomes
    Research focus
    recombination
    meiosis
  20. Job Dekker

    University of Massachusetts Medical School, United States

    Expertise
    Computational and Systems Biology
    Genes and Chromosomes
    Research focus
    spatial organisation of genomes
    chromatin interaction networks
  21. Timothy Formosa

    University of Utah, United States

    Expertise
    Genes and Chromosomes
    Research focus
    chromatin
    yeast genetics
    histone chaperones
    DNA replication
    transcription
    Experimental organism
    single-cell yeasts
  22. Thomas Gingeras

    Cold Spring Harbor Laboratory, United States

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    noncoding RNA
    genome organisation
    transcriptome analyses
    DNA sequencing methods
    Experimental organism
    Drosophila
  23. Michael R Green

    University of Massachusetts Medical School, United States

    Expertise
    Cancer Biology
    Genes and Chromosomes
    Human Biology and Medicine
    Research focus
    RNA splicing
    cancer molecular biology
  24. Rachel Green

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    mechanism of translation (bacterial and eukaryotic)
    ribosome profiling
    mRNA decay
    translational control
    ribosomes
  25. Edith Heard

    Reviewing Editor

    Expertise
    Genes and Chromosomes
    Research focus
    X-chromosome inactivation
    epigenetics
    nuclear organisation
    Experimental organism
    mouse
  26. Alan G Hinnebusch

    National Institute of Child Health and Human Development, United States

    Expertise
    Genes and Chromosomes
    Research focus
    protein synthesis
    translational control
  27. Torben Heick Jensen

    Aarhus University, Denmark

    Expertise
    Genes and Chromosomes
    Research focus
    RNA turnover
    RNA processing
    gene expression
    transcription
  28. Katherine Jones

    Salk Institute for Biological Studies, United States

    Expertise
    Genes and Chromosomes
    Research focus
    transcriptional mechanisms
    transcription mechanisms
    HIV gene expression
    APC / regulation of expression of growth control genes
  29. Karla Kirkegaard

    Stanford University School of Medicine, United States

    Expertise
    Genes and Chromosomes
    Microbiology and Infectious Disease
    Research focus
    drug resistance
    viral evolution
    dominant genes
    Experimental organism
    human
    mouse
    viruses
  30. Stephen C Kowalczykowski

    University of California, Davis, United States

    Expertise
    Biochemistry and Chemical Biology
    Biophysics and Structural Biology
    Genes and Chromosomes
    Research focus
    recombinational DNA repair
    single-molecule biophysics
    DNA-protein interactions
    Experimental organism
    E. coli
    S. cerevisiae
    human
  31. Leonid Kruglyak

    University of California, Los Angeles, United States

    Expertise
    Genes and Chromosomes
    Research focus
    phenotypic variation
    genetics of global gene expression
    population genetics
    complex diseases
    Experimental organism
    C. elegans
    S. cerevisiae
  32. Jeannie T Lee

    Massachusetts General Hospital, United States

    Expertise
    Genes and Chromosomes
    Research focus
    noncoding RNA
    X-chromosome inactivation
    imprinting
    epigenetics
    chromatin
  33. Gail Mandel

    Oregon Health and Science University, United States

    Expertise
    Genes and Chromosomes
    Neuroscience
    Research focus
    neuronal gene expression
    astrocyte biology
  34. Andrew Morris

    University of Liverpool, United Kingdom

    Expertise
    Computational and Systems Biology
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    statistical genetics
    genetic epidemiology
    methodological development
    genome-wide association studies
  35. Timothy Nilsen

    Case Western Reserve University, United States

    Expertise
    Biochemistry and Chemical Biology
    Genes and Chromosomes
    Research focus
    mRNA processing
    mechanism of miRNA function
    RNA protein interactions
    mRNP composition and function
    RNA biology
    Experimental organism
    Drosophila
  36. Nick J Proudfoot

    Oxford University, United Kingdom

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    mRNA processing
    transcription
  37. Danny Reinberg

    New York University, United States

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    epigenetics
    chromatin biology
    chromatin
    histones
    transcription
  38. Ali Shilatifard

    Northwestern University Feinberg School of Medicine, United States

    Expertise
    Biochemistry and Chemical Biology
    Cancer Biology
    Genes and Chromosomes
    Research focus
    chromatin
    ELLs
    P-TEFb
    pol II
    MLLs
    chromosomal translocations and leukemia
    enhancers
    gene expression
    transcription
    Experimental organism
    Drosophila
  39. Robert H Singer

    Albert Einstein College of Medicine, United States

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    transcription
    mRNA localization
  40. Nahum Sonenberg

    McGill University, Canada

    Expertise
    Genes and Chromosomes
    Neuroscience
    Research focus
    protein synthesis
    cell signalling and translation
    translational control of memory
  41. Allan Spradling

    Carnegie Institution for Science, United States

    Expertise
    Developmental Biology and Stem Cells
    Genes and Chromosomes
    Research focus
    stem cell differentiation and morphogenesis
    ovary
    female reproduction
    polyploid cell
    epigenetics
    Experimental organism
    Drosophila
  42. Jonathan P Staley

    University of Chicago, United States

    Expertise
    Cell Biology
    Genes and Chromosomes
    Research focus
    catalysis
    proofreading
    RNA dynamics
  43. Juan Valcárcel

    Centre for Genomic Regulation, Spain

    Expertise
    Genes and Chromosomes
    Research focus
    RNA processing
    gene regulation
  44. Cynthia Wolberger

    Johns Hopkins University School of Medicine, United States

    Expertise
    Biophysics and Structural Biology
    Genes and Chromosomes
    Research focus
    x-ray crystallography
    enzymology
    transcriptional regulation
    ubiquitin signaling
  45. Jerry L Workman

    Stowers Institute for Medical Research, United States

    Expertise
    Developmental Biology and Stem Cells
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Research focus
    protein complexes
    chromatin modification
    regulation of gene transcription
    Experimental organism
    S. cerevisiae
  46. Yukiko M Yamashita

    Howard Hughes Medical Institute, University of Michigan, United States

    Expertise
    Cell Biology
    Developmental Biology and Stem Cells
    Genes and Chromosomes
    Research focus
    stem cells
    stem cell niche
    asymmetric division
    spindle orientation
    centrosome
    Experimental organism
    D. melanogaster
  47. Daniel Zilberman

    University of California, Berkeley, United States

    Expertise
    Genes and Chromosomes
    Genomics and Evolutionary Biology
    Plant Biology
    Research focus
    chromatin biology
    epigenetics
    epigenomics
    evolution
    Experimental organism
    rice
    arabidopsis thaliana