September 2013

Research articles

    1. Plant Biology

    Phenotypic landscape inference reveals multiple evolutionary paths to C4 photosynthesis

    Ben P Williams et al.
    Computational modelling indicates that C4 photosynthesis in distantly related plant species arose through a number of independent evolutionary paths.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Genes and Chromosomes

    Direct observation of frequency modulated transcription in single cells using light activation

    Daniel R Larson et al.
    Steroid hormone receptors control the expression of their target genes through a digital on-off switch in individual cells, which leads to an analogue dose-response relationship at the level of the whole organism.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

    Manchuta Dangkulwanich et al.
    Quantification of all the major on- and off-pathway kinetic parameters in the transcription elongation cycle reveals that RNA polymerase II translocates slowly in a linear, non-branched Brownian ratchet mechanism.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez et al.
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway

    Ainhoa Pérez-Garijo et al.
    A common mechanism might regulate the communal death of cells in flies and mammals.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Cell Biology

    Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

    Ivana Primorac et al.
    The spindle assembly protein Bub3 recruits the checkpoint kinase Bub1 to kinetochores by binding to phosphorylated MELT repeats in the kinetochore subunit Knl1.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons

    Caitlin Engelhard et al.
    A protein called Megf8 regulates the activity of key signaling molecules involved in the development of the peripheral nervous system.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Cell Biology

    Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

    Matthew A Cottee et al.
    Structural analyses of the centriole proteins CPAP and STIL identify domains that are critical for centriole formation and provide a structural explanation for a mutation that causes human microcephaly.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble et al.
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Caveolae internalization repairs wounded cells and muscle fibers

    Matthias Corrotte et al.
    Cells repair damage to their outer membranes not by patching them as previously thought, but by using proteins called caveolins to remove the damaged regions by endocytosis.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    An essential role for maternal control of Nodal signaling

    Pooja Kumari et al.
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells

    Yaping Sun et al.
    A chemical screen reveals that a compound used to treat a parasitic disease can trigger pluripotent stem cells to become neurons, uncovering a novel mechanism behind neuronal development.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    Tissue absence initiates regeneration through Follistatin-mediated inhibition of Activin signaling

    Michael A Gaviño et al.
    Flatworm regeneration of lost tissue relies on a mechanism distinct from that used for routine tissue turnover.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Genomics and Evolutionary Biology

    DNA methylation presents distinct binding sites for human transcription factors

    Shaohui Hu et al.
    A comprehensive study of human transcription factors reveals that a greater number of these proteins bind to methylated DNA sequences than previously thought.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum et al.
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    High-order social interactions in groups of mice

    Yair Shemesh et al.
    Tracking individual mice within a group makes it possible to quantify and model social behavior, and reveals that the behavior of the group goes beyond pairwise interactions, and is shaped by complex interactions between multiple individuals.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation

    Benjamin A Smith et al.
    New insights into the mechanism responsible for the nucleation of branches on networks of actin filaments shed light on a process that is essential for eukaryotic cell motility and endocytosis.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló et al.
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    Mechanism of synergistic activation of Arp2/3 complex by cortactin and N-WASP

    Luke A Helgeson, Brad J Nolen
    Single-molecule TIRF microscopy, biochemical assays and mathematical modeling demonstrate how actin-branch nucleation by the Arp2/3 complex is coordinately regulated by two biochemically distinct activators.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions

    Shigeki Watanabe et al.
    Optogenetics has revealed that synaptic vesicles can be recycled extremely rapidly in nematodes, indicating that existing models for how synapses 'reload' may need to be revised.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf