February 2016

Research articles

    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

    Durafshan Sakeena Syed et al
    Signaling from glia and nerves regulate the development of axonal and dendritic motor neuron architecture, needed for walking in the fruit fly species Drosophila.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Cell Biology

    Regulation by the quorum sensor from Vibrio indicates a receptor function for the membrane anchors of adenylate cyclases

    Stephanie Beltz et al
    A canonical class III adenylate cyclase with a membrane anchor of six transmembrane spans is regulated by a receptor of similar design, the quorum-sensing receptor from Vibrio harveyi.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Genes and Chromosomes

    The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis

    Saravanapriah Nadarajan et al
    Coordination between crossover designation and synaptonemal complex disassembly is executed via a conserved MAP kinase pathway and is critical for accurate chromosome segregation during meiosis.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Conditioned respiratory threat in the subdivisions of the human periaqueductal gray

    Olivia K Faull et al
    High-resolution imaging shows that the different columns of the human periaqueductal gray play differential roles in the response to a respiratory threat.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Endocannabinoid dynamics gate spike-timing dependent depression and potentiation

    Yihui Cui et al
    The molecular mechanisms beyond the bidirectionality (tTLP and tLTD) of endocanabinoid spike-timing dependent synaptic plasticity have been identified.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Human Biology and Medicine

    Transcriptional activator TAp63 is upregulated in muscular atrophy during ALS and induces the pro-atrophic ubiquitin ligase Trim63

    Yannick von Grabowiecki et al
    Atrophic muscles of patients and animal models developing amyotrophic lateral sclerosis show an upregulation of TAp63 that stimulates the expression of a pro-atrophic ubiquitin ligase.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Yeast Eps15-like endocytic protein Pan1p regulates the interaction between endocytic vesicles, endosomes and the actin cytoskeleton

    Junko Y Toshima et al
    Phosphorylation of the Eps15-like protein Pan1p regulates how endocytic compartments interact with each other and with the actin cytoskeleton.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis

    Seung-Hyun Ro et al
    Sestrin2 loss could be a universal mechanism of human colon carcinogenesis that allows for barrier dysfunction, mTORC1 hyperactivation, unrestricted tumor growth and chemoresistance.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Pre-transition effects mediate forces of assembly between transmembrane proteins

    Shachi Katira et al
    A general mechanism for how powerful forces of assembly and protein mobility can emerge from phase transitions is established.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Immunology

    The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation

    Agnieszka M Kabat et al
    Impaired autophagy influences intestinal inflammation and hypersensitivity responses by orchestrating mucosal T cell populations, suggesting new translational perspectives for the treatment of these conditions.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Neuroscience

    Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

    Santiago Vernia et al
    Metabolic stress-induced activation of the JNK3 protein regulates excitatory transmission onto AgRP neurons to regulate food consumption.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Temporal modulation of collective cell behavior controls vascular network topology

    Esther Kur et al
    Tissue-specific temporal regulators impinge on the VEGF/Delta-Notch pathway to vary tip cell selection pace yielding diverse densities of vascular network.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Evaluating probabilistic dengue risk forecasts from a prototype early warning system for Brazil

    Rachel Lowe et al
    The evaluation of a dengue early warning system demonstrates its potential to assist dengue prevention and control up to three months ahead of future epidemics.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Developmental Biology and Stem Cells

    Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin

    Emiko Mihara et al
    Lipidated and highly hydrophobic Wnt ligands form a complex with the serum glycoprotein afamin, and can be purified and stored in a biologically active form without detergents.
    Tools and Resources
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Human Biology and Medicine

    Mitochondrial DNA copy number variation across human cancers

    Ed Reznik et al
    Many tumors are depleted of mitochondrial DNA; this depletion is associated with changes in gene expression and with the incidence of critical somatic mutations and alterations.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology
    2. Neuroscience

    Resolving rates of mutation in the brain using single-neuron genomics

    Gilad D Evrony et al
    The reanalysis of data from a recent study that claimed retrotransposon mutations are ubiquitous in the human brain outlines a general framework for the design and analysis of single-cell genomics studies.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Genes and Chromosomes

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte et al
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    A genome-wide resource for the analysis of protein localisation in Drosophila

    Mihail Sarov et al
    A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of Drosophila development.
    Tools and Resources
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Genes and Chromosomes

    A continuum model of transcriptional bursting

    Adam M Corrigan et al
    Rather than switching between discrete on and off states, gene transcription exists in a spectrum or continuum of states, with a slowly changing initiation rate modulating the levels of activity.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Binary architecture of the Nav1.2-β2 signaling complex

    Samir Das et al
    X-ray crystallography reveals new conceptual insights into the location of the β2-subunit in the Nav channel signaling complex.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Immunology

    Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

    Anthony J Covarrubias et al
    Interleukin 4 signaling co-opts the Akt-mTORC1-Acly pathway to couple metabolic input to the control of energetically demanding processes during macrophage M2 activation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Neuroscience

    Regulatory consequences of neuronal ELAV-like protein binding to coding and non-coding RNAs in human brain

    Claudia Scheckel et al
    Neuronal ELAV-like (nELAVL) proteins are associated with non-coding Y RNAs in stressed neurons and in the brains of Alzheimer's disease patients, suggesting a new means of regulatory protein sequestration and mRNA target regulation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Biophysics and Structural Biology

    Stepwise nucleosome translocation by RSC remodeling complexes

    Bryan T Harada et al
    Single molecule FRET reveals that the SWI/SNF-family remodeling enzyme RSC translocates nucleosomes along the DNA in steps of ~1-2 base pairs in size.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Cascade of neural processing orchestrates cognitive control in human frontal cortex

    Hanlin Tang et al
    A dynamic and hierarchical sequence of steps in human frontal cortex orchestrates cognitive control.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524

    Anna P Baron et al
    Chemical inhibition of Bub1 shows that the catalytic activity is not required for normal mitotic progression, but it makes chromosome segregation and cell proliferation more sensitive to the effects of the anti-cancer drug Paclitaxel.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex

    Wei Zhang et al
    During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells

    Bicoid gradient formation and function in the Drosophila pre-syncytial blastoderm

    Zehra Ali-Murthy, Thomas B Kornberg
    The concentration gradient of Bicoid protein positions gene expression domains along the anterior/posterior axis of the Drosophila embryo during the cleavage, pre-syncytial blastoderm stages.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genes and Chromosomes

    Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis

    Candice L Wike et al
    A histone modification that alters the nucleosome structure occurs in mitosis and promotes chromosome packaging and the timely removal of condensin I and cohesion, to achieve chromosome segregation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Microbiology and Infectious Disease

    Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection

    Eleanor Gaunt et al
    Mutants of influenza A virus with increased CpG dinucleotide frequencies show restricted replication and reduced or absent pathogenicity, and powerful host innate and adaptive responses to infection that confer immunity to re-infection.
    Research Advance
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Immunology

    Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

    Jennifer C Regan et al
    In the fruit fly Drosophila melanogaster, stem cell activity ages female guts but not male guts; furthermore, males with feminized guts develop pathologies but gain an increase in lifespan through dietary restriction.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Neuroscience

    Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice

    Damien Lanfray et al
    The Acyl-CoA binding domain-containing 7 (Acbd7) gene is expressed in the hypothalamus, encodes a peptide that suppresses appetite, increases metabolic rate and interacts with the leptin-melanocortin system.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Neuroscience

    Prediction of primary somatosensory neuron activity during active tactile exploration

    Dario Campagner et al
    Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    A circuit mechanism for the propagation of waves of muscle contraction in Drosophila

    Akira Fushiki et al
    Coordinated activation and deactivation of inhibitory neurons triggers sequential muscle contractions that enable fruit fly larvae to propel themselves backwards and forwards.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein

    Max Renner et al
    A structural comparison of different states of the protein responsible for encapsidation of the viral RNA genome provides mechanistic insights into this process.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Neuronal processing of noxious thermal stimuli mediated by dendritic Ca2+ influx in Drosophila somatosensory neurons

    Shin-Ichiro Terada et al
    Drosophila polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca2+ influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    A synergy-based hand control is encoded in human motor cortical areas

    Andrea Leo et al
    The human brain encodes coordinated patterns of joint movements – synergies – to increase the efficiency with which it can control complex hand movements.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Bitter taste receptors confer diverse functions to neurons

    Rebecca Delventhal, John R Carlson
    Expression of Drosophila bitter receptors in taste neurons produced increased, decreased, or novel responses, supporting a model in which the response profile is determined by activation, inhibition, or competition among receptors.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biochemistry
    2. Cell Biology

    Aurkb/PP1-mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells

    Jihoon Shin et al
    The regulation of the core transcription factor Oct4 by the Aurkb-PP1 axis links the cell cycle to pluripotency programs in embryonic stem cells.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology
    2. Human Biology and Medicine

    Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

    Prithvi Raj et al
    Genetic variations that underlie common autoimmune disease genes are predominantly regulatory and modify the expression of multiple genes within the HLA gene complex and throughout the immune system.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology

    More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

    Alison F Feder et al
    The transition from bad to good treatments for HIV was accompanied by a shift from soft sweeps of many drug resistance mutations spreading simultaneously to harder sweeps of one drug resistant genotype at a time.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

    Alexis B Webb et al
    Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    An external sodium ion binding site controls allosteric gating in TRPV1 channels

    Andres Jara-Oseguera et al
    Allosteric gating in a transient receptor potential channel is modulated by external sodium ions and a tarantula toxin.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Identity of neocortical layer 4 neurons is specified through correct positioning into the cortex

    Koji Oishi et al
    Layer 4 neuronal identity is specified by Protocadherin20 positioning the neurons into layer 4 so that they receive a positional cue from thalamocortical axons.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval

    Vanessa Lux et al
    The retrieval of recent memories and very remote memories may rely on distinct regions of the hippocampus.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Membrane palmitoylated protein 2 is a synaptic scaffold protein required for synaptic SK2-containing channel function

    Gukhan Kim et al
    A new synaptic scaffold important for neurotransmission and synaptic plasticity has been identified.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Immunology

    Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent

    Luise Westernberg et al
    Antagonistic signaling by the kinases PI3K and Itpkb limits the kinetics and enforces the Notch-dependence of beta-selection – the most important cell-fate determining process in alpha beta T cell development.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

    Thirumalini Vaithianathan et al
    A combination of tethered diffusion of release-ready synaptic vesicles and vesicle-vesicle fusion supports neurotransmitter release at the presynaptic active zone of sensory synapses.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Neuroscience

    Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep

    Kun-Ming Ni et al
    Cholinergic system play an important role in waking-to-sleep cycles and in sleep stabilization.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Genes and Chromosomes

    TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells

    Barbora Malecova et al
    Genetic and biochemical evidence shows that the basal transcription machinery of muscle cells invariably relies on TBP/TFIID because TBP2 is not expressed in muscle cells, and thus resolves a longstanding issue raised by previous conflicting data.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Active sensing in the categorization of visual patterns

    Scott Cheng-Hsin Yang et al
    Humans use a near-optimal eye movement strategy to efficiently extract information about high-level visual categories.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Structural insights into the mechanism of activation of the TRPV1 channel by a membrane-bound tarantula toxin

    Chanhyung Bae et al
    The structure of a bivalent double-knot tarantula toxin bound to the outer pore of the capsaicin receptor reveals a novel mode of toxin-channel recognition that has important implications for thermosensation.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Microbiology and Infectious Disease

    Cyanobacteria use micro-optics to sense light direction

    Nils Schuergers et al
    The cells of a cyanobacterium act as spherical micro-lenses, allowing the cell to see a light source and move towards it.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology

    Preservation of three-dimensional anatomy in phosphatized fossil arthropods enriches evolutionary inference

    Achim H Schwermann et al
    X-ray imaging reveals well-preserved internal characters in mineralized arthropods from the Paleogene, urging the reexamination of previously neglected fossil collections.
    Tools and Resources
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death

    Fabrice Bouilloux et al
    The transcription factor Meis1 is a dedicated maintenance factor for sympathetic neurons and controls the expression of key genes involved in endosome trafficking.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Neuroscience

    Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

    Lei Xing et al
    Aberrant ERK/MAPK signaling in cortical pyramidal neurons leads to selective disruption of layer 5 circuit development and generalized changes in neuronal excitability.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling

    Claudio A Franco et al
    A threshold level of blood flow initiates developmental blood vessel regression; this threshold can be regulated by non-canonical Wnt ligands.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genes and Chromosomes

    Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes

    Oliver Crawley et al
    By specifically antagonizing binding of complexes carrying COH-3/4 kleisins, WAPL-1 regulates chromosome structure and cohesion throughout meiotic prophase.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genes and Chromosomes
    2. Microbiology and Infectious Disease

    Recombinational branch migration by the RadA/Sms paralog of RecA in Escherichia coli

    Deani L Cooper, Susan T Lovett
    The role of the bacterial protein RadA in homologous recombination – a DNA repair pathway vital to all cells – is defined.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Computational and Systems Biology

    Active machine learning-driven experimentation to determine compound effects on protein patterns

    Armaghan W Naik et al
    In an investigation into the effects of drugs on proteins, an active machine learning algorithm chose which sets of experiments to perform and was able to learn an accurate model of the effects after doing only a fraction of the experiments.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Plant Biology

    PCH1 integrates circadian and light-signaling pathways to control photoperiod-responsive growth in Arabidopsis

    He Huang et al
    A conserved, circadian-regulated protein alters light perception in plants to regulate daily growth in response to changing photoperiod.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    Localized epigenetic silencing of a damage-activated WNT enhancer limits regeneration in mature Drosophila imaginal discs

    Robin E Harris et al
    Localized silencing of damage-responsive enhancers can block regenerative growth while permitting those same genes to be used for normal development.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades

    Lars Hering et al
    A newly discovered cytoplasmic intermediate filament in water bears may help these animals to resist extreme environmental conditions.
    Short Report
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    A mathematical model explains saturating axon guidance responses to molecular gradients

    Huyen Nguyen et al
    Mathematical modelling explains why molecular gradients sometimes cause axons to only turn weakly.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Correlated magnetic resonance imaging and ultramicroscopy (MR-UM) is a tool kit to assess the dynamics of glioma angiogenesis

    Michael O Breckwoldt et al
    Correlated magnetic resonance imaging and ultramicroscopy resolves macro- and microvasculature in glioma models and allows treatment monitoring of antiangiogenic therapy.
    Tools and Resources
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology

    Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

    Amy M Winans et al
    Waves of polymerizing actin work in concert with microtubule polymerization to lay down more microtubules tracks and transiently increase microtubule-based transport into the growing neurite.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology

    Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

    Diana M Mitrea et al
    Nucleolar protein localization involves the phase separation within the nucleolar matrix via three types of multivalent features: acidic tracts, nucleic acid binding domains and arginine-rich low complexity sequences.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai et al
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Immunology

    Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

    Akira Takeda et al
    A lipid mediator lysophosphatidic acid (LPA) derived from fibroblastic reticular cells regulates T-cell movement through the densely packed reticular network in lymph nodes in a manner dependent on the LPA receptor LPA2-ROCK-myosin II.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Genomics and Evolutionary Biology

    Fast turnover of genome transcription across evolutionary time exposes entire non-coding DNA to de novo gene emergence

    Rafik Neme, Diethard Tautz
    Deep sequencing of transcriptomes from closely related taxa shows that the whole genome can become subject to evolutionary testing within a short time frame via de novo evolution of genes.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Neuroscience

    Dopamine regulates stimulus generalization in the human hippocampus

    Thorsten Kahnt, Philippe N Tobler
    Inhibition of dopamine D2 receptors reduces generalization between stimuli, possibly by reducing interactions between the hippocampus and midbrain.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Human Biology and Medicine
    2. Neuroscience

    Mapping oxygen concentration in the awake mouse brain

    Declan G Lyons et al
    Two-photon phosphorescence lifetime microscopy reveals the physiological values of oxygen concentration and blood flow parameters in the brains of awake mice.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Biophysics and Structural Biology
    2. Human Biology and Medicine

    Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

    Sean W Fanning et al
    Two common mutant versions of estrogen receptor alpha achieve constitutive activity and hormone-resistance by preferentially adopting a suite of conformations that expose the coregulator-binding surface.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Developmental Biology and Stem Cells
    2. Genes and Chromosomes

    Maternal LSD1/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation

    Katia Ancelin et al
    The maternally provided histone demethylase LSD1/KDM1A has an instrumental role at the beginning of life, shaping the histone methylation landscape and the transcriptional repertoire of the early mouse embryo.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea

    Arzu Öztürk-Çolak et al
    Cell-cell junctions and the actin cytoskeleton are key players in the organisation and patterning of the extracellular matrix (ECM) on the apical side of tracheal cells.
    Research Article
    Available as full, typeset article htmlAvailable as authors' accepted manuscript pdf

Magazine

  1. Paleontology

    Paleontology: A Collection of Articles

    Curated by Ian Baldwin et al.